Revista Española de Cardiología (English Edition) Revista Española de Cardiología (English Edition)
Rev Esp Cardiol. 2010;63:286-93 - Vol. 63 Num.03 DOI: 10.1016/S1885-5857(10)70061-X

Aspirin, Non-Aspirin Analgesics and the Risk of Hypertension in the SUN Cohort

Juan José Beunza a, Miguel Ángel Martínez-González b, Maira Bes-Rastrollo b, Jorge María Núñez-Córdoba b, Estefanía Toledo c, Álvaro Alonso d

a Departamento de Medicina Preventiva y Salud Pública, Facultad de Medicina, Universidad de Navarra, Clínica Universidad de Navarra, Pamplona, Navarra, Spain. Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts, USA
b Departamento de Medicina Preventiva y Salud Pública, Facultad de Medicina, Universidad de Navarra, Clínica Universidad de Navarra, Pamplona, Navarra, Spain
c Departamento de Medicina Preventiva y Salud Pública, Facultad de Medicina, Universidad de Navarra, Clínica Universidad de Navarra, Pamplona, Navarra, Spain. Servicio de Medicina Preventiva, Hospital Virgen del Camino, Pamplona, Navarra, Spain
d Departamento de Medicina Preventiva y Salud Pública, Facultad de Medicina, Universidad de Navarra, Clínica Universidad de Navarra, Pamplona, Navarra, Spain. Division of Epidemiology and Community Health, School of Public Health, University of Minnesota, Minneapolis, Minnesota, USA

Keywords

Hypertension. Analgesics. Aspirin. SUN project. Cohorts.

Abstract

ntroduction and objectives. The use of aspirin and non-aspirin analgesics have been associated with changes in blood pressure. The aim of this study was to investigate prospectively the association between the regular use of aspirin and non-aspirin analgesics and the incidence of hypertension. Methods. The SUN project is an ongoing, continuously expanding, prospective cohort of Spanish university graduates initially free of hypertension, cardiovascular disease, diabetes, and cancer; 9986 (mean age, 36 years) were recruited during 1999-2005 and followed up for a mean of 51 months. Regular aspirin and non-aspirin analgesic use and the presence of other risk factors for hypertension were assessed by questionnaire at baseline, and the incidence of hypertension was assessed using biennial follow-up questionnaires. Results. In total, 543 new cases of hypertension were identified during follow-up. Regular aspirin use (ie, ≥2 days/ week) was associated with a higher risk of hypertension (hazard ratio = 1.45; 95% confidence interval, 1.02-2.04) after adjustment for various confounding factors. Regular use of non-aspirin analgesic drugs was also associated with a higher risk of hypertension (hazard ratio = 1.69; 95% confidence interval, 1.28-2.23). Conclusions. The regular use of aspirin and non-aspirin analgesics were both associated with an increased risk of developing hypertension, independently of other risk factors.

1885-5857/© 2010 Sociedad Española de Cardiología. Published by Elsevier España, S.L.U. All rights reserved

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