Revista Española de Cardiología (English Edition) Revista Española de Cardiología (English Edition)
Rev Esp Cardiol. 2008;61:269-75 - Vol. 61 Num.03 DOI: 10.1016/S1885-5857(08)60114-0

Association Between Paraoxonase-1 and Paraoxonase-2 Polymorphisms and the Risk of Acute Myocardial Infarction

Mònica Guxens a, Marta Tomás b, Roberto Elosua c, Elena Aldasoro d, Antonio Segura e, Miquel Fiol f, Joan Sala g, Joan Vila b, Maria Fullana h, Mariano Sentí i, Gema Vega e, Mónica de la Rica d, Jaume Marrugat j

a Unitat de Lípids i Epidemiologia Cardiovascular, Institut Municipal d'Investigació Mèdica, Barcelona, Spain. Unitat Docent de Medicina Preventiva i Salut Pública, IMAS-UPF-ASPB, Barcelona, Spain. Universitat Autònoma de Barcelona, Bellaterra, Barcelona, Spain
b Unitat de Lípids i Epidemiologia Cardiovascular, Institut Municipal d'Investigació Mèdica, Barcelona, Spain
c Unitat de Lípids i Epidemiologia Cardiovascular, Institut Municipal d'Investigació Mèdica, Barcelona, Spain. CIBER Epidemiología y Salud Pública (CIBERESP), Spain
d Departamento de Sanidad del Gobierno Vasco, Vitoria-Gasteiz, Álava, Spain
e Instituto de Ciencias de la Salud, Consejería de Sanidad de Castilla-La Mancha, Talavera de la Reina, Toledo, Spain
f Unitat Coronària, Hospital Universitari Son Dureta, Palma de Mallorca, Mallorca, Spain. Centro de Investigación en RED de Obesidad y Nutrición (CIBERobn), Instituto Carlos III, Madrid, Spain
g Unitat Coronària, Hospital Josep Trueta, Girona, Spain
h Servei de Medicina Interna, Hospital Universitari Son Dureta, Palma de Mallorca, Mallorca, Spain
i Unitat de Lípids i Epidemiologia Cardiovascular, Institut Municipal d'Investigació Mèdica, Barcelona, Spain. Departament de Ciències Experimentals i de la Salut, Universitat Pompeu Fabra, Barcelona, Spain
j Unitat de Lípids i Epidemiologia Cardiovascular, Institut Municipal d'Investigació Mèdica, Barcelona, Spain. Universitat Autònoma de Barcelona, Bellaterra, Barcelona, Spain

Keywords

Coronary disease. Genetics. Antioxidants. Enzymes. High-density lipoprotein (HDL).

Abstract

Introduction and objectives. Two particular polymorphisms, namely PON1-192 and PON2-311, in the genes encoding the antioxidant enzymes paraoxonase-1 (PON1) and paraoxonase-2 (PON2) have been associated with an increased risk of acute myocardial infarction (AMI). However, previous findings have been contradictory. The aim of this study was to investigate the association between the PON1-192 and PON2-311 polymorphisms and their interaction on AMI risk. Methods. This case-control study involved 746 consecutive AMI patients and 1796 control subjects without cardiovascular disease, who were randomly selected from the same population from which the patients came. All participants were recruited between 1999 and 2000 from four Spanish autonomous regions. All were assessed for the presence of PON1-192 and PON2-311 and for classical cardiovascular risk factors. Multivariate analysis was carried out using logistic regression modeling. Results. The odds ratios (OR) of AMI for patients with the PON1-192 QQ and PON2-311 SS genotypes (who comprised 50% and 66% of the population, respectively) were 1.26 (95% confidence interval [CI], 1.02­1.55) and 1.25 (95% CI, 1.04­1.50), respectively, compared with R and C allele carriers. Moreover, in patients with both QQ and SS genotypes, the adjusted OR of AMI increased to 1.41 (95% CI, 1.13­1.76). Conclusions. Our results indicate that the PON1-192 and PON2-311 polymorphisms were independent risk factors of AMI in our population.

1885-5857/© 2008 Sociedad Española de Cardiología. Published by Elsevier España, S.L.U. All rights reserved

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