Revista Española de Cardiología (English Edition) Revista Española de Cardiología (English Edition)
Rev Esp Cardiol. 2012;65:1086-93 - Vol. 65 Num.12 DOI: 10.1016/j.rec.2012.04.019

Carotid Intima-media Thickness in the Spanish Population: Reference Ranges and Association With Cardiovascular Risk Factors

Maria Grau a,, Isaac Subirana a,b, David Agis b,c, Rafel Ramos d, Xavier Basagaña b,c, Ruth Martí d, Eric de Groot e, Roman J. Arnold f, Jaume Marrugat a, Nino Künzli g,h, Roberto Elosua a,b

a Grup d’Epidemiologia i Genètica Cardiovascular, Programa de Recerca en Processos Inflammatoris i Cardiovasculars, IMIM-Institut Hospital del Mar d’Investigacions Mèdiques, Barcelona, Spain
b CIBER Epidemiología y Salud Pública (CIBERESP), Spain
c Centre de Recerca en Epidemiologia Ambiental (CREAL), Barcelona, Spain
d Unitat de Recerca en Atenció Primària de Girona, Institut d’Investigació en Atenció Primària (IDIAP) Jordi Gol i Unitat Docent de Medicina de Família de Girona, Institut Català de la Salut (ICS), Girona, Spain
e Academic Medical Centre, University of Amsterdam, Amsterdam, The Netherlands
f ICICORELAB, Hospital Clínico Universitario, Valladolid, Spain
g Swiss Tropical and Public Health Institute (SwissTPH), Basel, Switzerland
h University of Basel, Basel, Switzerland

Refers to

Carotid Intima-media Thickness and Morbidity and Mortality in Spain: A Definitive Prospective Study Is Needed
Alberto Cordero, Lorenzo Fácila, Eduardo Alegría, Enrique Galve
Rev Esp Cardiol. 2013;66:325-6
Full text - PDF
Predictors of Carotid Intima-media Thickness
Pedro E. Miguel-Soca, Silvio Niño-Escofet
Rev Esp Cardiol. 2013;66:326-7
Full text - PDF

Keywords

Carotid intima-media thickness. Carotid ultrasonography. Cardiovascular risk factors. Preclinical atherosclerosis. Cardiovascular risk.

Abstract

Introduction and objectives

Carotid intima-media thickness as measured with ultrasonography is an inexpensive and noninvasive predictor of cardiovascular events. The objectives of this study were to determine the population reference ranges of carotid intima-media thickness for individuals aged 35-84 years in Spain and to analyze the association of carotid intima-media thickness with cardiovascular risk factors (age, smoking, diabetes, pulse pressure, lipid profile, and body mass index).

Methods

Population-based cross-sectional study conducted in Gerona (Spain). We described the mean and maximal values of carotid intima-media thickness of the carotid artery and of its 3 segments (common carotid, carotid bulb and internal carotid). We assessed cardiovascular risk factors and analyzed their association with carotid intima-media thickness using adjusted linear regression models.

Results

A total of 3161 individuals (54% women) were included, with mean age 58 years. Men showed significantly higher mean common carotid intima-media thickness than did women (0.71 vs 0.67mm). The strongest predictors of this measure were age (coefficients for 10-year increase: 0.65 and 0.58 for women and men, respectively), smoking in men (coefficient: 0.26), high-density lipoprotein cholesterol in women (coefficient for 10mg/dL, increase: −0.08) and pulse pressure in both sexes (coefficients for 10mmHg increase: 0.08 and 0.23 for women and men, respectively). The results were similar for the mean carotid intima-media thickness of all the segments.

Conclusions

This population-based study presents the reference ranges for carotid intima-media thickness in the Spanish population. The main determinants of carotid intima-media thickness were age and pulse pressure in both sexes.

1885-5857/© 2012 Sociedad Española de Cardiología. Published by Elsevier España, S.L.U. All rights reserved

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