Revista Española de Cardiología (English Edition) Revista Española de Cardiología (English Edition)
Rev Esp Cardiol. 2014;67:353-8 - Vol. 67 Num.05 DOI: 10.1016/j.rec.2013.09.003

Effectiveness and Safety Beyond 10 Years of Percutaneous Transluminal Septal Ablation in Hypertrophic Obstructive Cardiomyopathy

José M. de la Torre Hernandez a,, Monica Masotti Centol b, Piedad Lerena Saenz a, Ángel Sánchez Recalde c, Federico Gimeno de Carlos d, Pablo Piñón Esteban e, Diego Fernandez Rodriguez b, Marta Sitges Carreño f, Manel Sabate Tenas b, Javier Zueco Gil a

a Unidad de Hemodinámica y Cardiología Intervencionista, Servicio de Cardiología, Hospital Universitario Marqués de Valdecilla, Santander, Spain
b Unidad de Hemodinámica y Cardiología Intervencionista, Servicio de Cardiología, Institut del Tórax, Hospital Clínic, Universitat de Barcelona, Barcelona, Spain
c Unidad de Hemodinámica y Cardiología Intervencionista, Servicio de Cardiología, Hospital Universitario La Paz, Madrid, Spain
d Unidad de Hemodinámica y Cardiología Intervencionista, Servicio de Cardiología, Hospital Clínico Universitario de Valladolid, Valladolid, Spain
e Unidad de Hemodinámica y Cardiología Intervencionista, Servicio de Cardiología, Complejo Hospitalario Universitario de A Coruña, A Coruña, Spain
f Sección de Imagen Cardiaca, Servicio de Cardiología, Institut del Tórax, Hospital Clínic, IDIBAPS, Universitat de Barcelona, Barcelona, Spain

Refers to

 Effectiveness and Safety Beyond 10 Years of Percutaneous Transluminal Septal Ablation in Hypertrophic Obstructive Cardiomyopathy
José M. de la Torre Hernandez, Monica Masotti Centol, Piedad Lerena Saenz, Ángel Sánchez Recalde, Federico Gimeno de Carlos, Pablo Piñón Esteban, Diego Fernandez Rodriguez, Marta Sitges Carreño, Manel Sabate Tenas, Javier Zueco Gil
Rev Esp Cardiol. 2014;67:353-8
Abstract - Full text - PDF

Keywords

Hypertrophic cardiomyopathy. Catheter septal ablation. Ventricular arrhythmia.

Abstract

Introduction and objectives

Percutaneous transluminal septal ablation is an alternative treatment in patients with hypertrophic obstructive cardiomyopathy. However, due to the relatively new introduction of this technique, there is no information on its very long term results (>10 years).

Methods

The present study included consecutive patients treated in 5 centers between 1998 and 2003. We analyzed clinical, hemodynamic, and echocardiographic data at baseline and follow-up.

Results

A total of 45 patients were included; there were 31 (69%) women, the mean age was 62.4 (14) years, and 39 patients (86.6%) showed functional class III or IV. Septal thickness was 21.8 (3.5) mm, the peak resting gradient on echocardiography was 77 (39) mmHg, and mitral regurgitation was at least moderate in 22 patients (48.8%). During hospitalization, permanent pacemaker implantation was required in 3 patients and ventricular perforation (by pacing lead) occurred in 1 patient, requiring surgery. After a follow-up of 12.3 years (11.0-13.5 years), 2 patients (4.4%) died from cardiac causes (heart failure and posttransplantation), 3 patients required an implantable cardioverter-defibrillator (1 for primary prevention and 2 due to sustained ventricular tachycardia after cardiac surgery), and 2 underwent cardiac surgery (due to endocarditis and mitral regurgitation). In the last clinical review, functional class was I-II in 39 patients (86.6%) (P<.0001), the peak resting gradient was 16 (23) mmHg (P<.0001), and mitral regurgitation was absent or mild in 34 patients (75.5%) (P<.03).

Conclusions

The results of this study suggest that septal ablation is safe and effective in the very long term. The procedure was not associated with a significant incidence of sudden death or symptomatic ventricular arrhythmias.

1885-5857/© 2014 Sociedad Española de Cardiología. Published by Elsevier España, S.L.U. All rights reserved

Cookies
x
To improve our services and products, we use cookies (own or third parties authorized) to show advertising related to client preferences through the analyses of navigation customer behavior. Continuing navigation will be considered as acceptance of this use. You can change the settings or obtain more information by clicking here.
Cookies policy
x
To improve our services and products, we use cookies (own or third parties authorized) to show advertising related to client preferences through the analyses of navigation customer behavior. Continuing navigation will be considered as acceptance of this use. You can change the settings or obtain more information by clicking here.