Revista Española de Cardiología (English Edition) Revista Española de Cardiología (English Edition)
Rev Esp Cardiol. 2008;61:923-9 - Vol. 61 Num.09 DOI: 10.1016/S1885-5857(08)60252-2

Etiologic and Cardiovascular Risk Factors in Obese Children From Extremadura in Spain. Their Relationship With Insulin Resistance and Plasma Adipocytokine Levels

María D Torres a, María A Tormo a, Carlos Campillo a, María I Carmona a, Montaña Torres b, Mercedes Reymundo c, Purificación García b, José E Campillo a

a Departamento de Fisiología, Facultad de Medicina, Universidad de Extremadura, Badajoz, España,
b Centro de Salud San Jorge, Cáceres, España,
c Centro de Salud La Paz, Badajoz, España,

Keywords

Children. Obesity. Cardiovascular risk. Insulin resistance. Adipocytokines. Extremadura.

Abstract

Introduction and objectives. The aim was to investigate etiologic and cardiovascular risk factors in obese children from Extremadura, Spain, and their relationship with insulin resistance and plasma adipocytokine levels. Methods. The study included 373 children (age, 3-13 years) who were randomly selected from schools in the city and province of Badajoz and from two health centers in the Spanish autonomous community of Extremadura. Results. Some 9.5% of children were obese. Compared with normal weight children, obese children exhibited a greater weight gain in the first year of life (7.3±1.5 kg vs. 6.3±0.8 kg), were less physically active (9.6±7.2 h/week vs. 13.1±8.1 h/week), and had more screen time (18.0±12.4 h/week vs. 12.8±8.2 h/week), a lower high-density lipoprotein cholesterol level (46.0±11.4 mg/dL vs. 64.6±22.9 mg/dL), higher arterial systolic pressure (102.3±8.5 mmHg vs. 89.9±13.4 mmHg), increased insulin resistance (6.2±3.6 vs. 4.6±4.5), a higher level of leptinemia (24.8±13.8 ng/mL vs. 12.9±10.8 ng/mL) and a lower level of adiponectinemia (8.4±5.7 mg/mL vs. 15.6±7.9 mg/mL). Conclusions. Our findings demonstrate that there is a relationship between a sedentary lifestyle and the development of insulin resistance and altered adipocytokines levels in obese children, and that these changes are related to a number of cardiovascular risk factors.

1885-5857/© 2008 Sociedad Española de Cardiología. Published by Elsevier España, S.L.U. All rights reserved

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