Revista Española de Cardiología (English Edition) Revista Española de Cardiología (English Edition)
Rev Esp Cardiol. 2009;62(09):1022-31 - Vol. 62 Num.09 DOI: 10.1016/S1885-5857(09)73268-2

High-Density Lipoprotein Cholesterol and Cardiovascular Disease in Spanish Hypertensive Women. The RIMHA Study

Antonio Coca a, Luis Cea-Calvo b, José V. Lozano c, Verónica Inaraja b, Cristina Fernández-Pérez d, Jorge Navarro e, Álvaro Bonet e, Josep Redón f, on behalf of the RIMHA Study research group

a Unidad de Hipertensión Arterial, Servicio de Medicina Interna General, Instituto de Medicina y Dermatología, Hospital Clínic (IDIBAPS), Universidad de Barcelona, Barcelona, Spain
b Departamento de Investigación Clínica, Merck Sharp & Dohme de España, Madrid, Spain
c Centro de Salud Serrería 2, Valencia, Spain
d Unidad de Apoyo a la Investigación, Hospital Clínico Universitario San Carlos, Universidad Complutense de Madrid, Madrid, Spain
e Centro de Salud Salvador Pau, Valencia, Spain
f Unidad de Hipertensión Arterial, Hospital Clínico Universitario, Universidad de Valencia, Valencia, Spain

Keywords

Women. High-density lipoprotein cholesterol. Prevalence. Cardiovascular disease. Cross-sectional studies.

Abstract

Introduction and objectives. To determine the prevalence of a low high-density lipoprotein cholesterol (HDL-C) concentration in 11 042 hypertensive Spanish women aged ≥55 years, to identify factors associated with a low concentration, and to evaluate its relationship with cardiovascular disease (CVD). Methods. Analysis of RIMHA cross-sectional study findings. Data on demographic, biochemical and clinical variables were obtained. Relationships between a low HDL-C concentration ( <46 mg dl and cvd between the hdl-c concentration in quintiles were studied by multivariate logistic regression modeling results prevalence of a low was 24 3 95 confidence interval ci 23 5 minus 25 1 higher women with diabetes or independently associated excess weight smoking presence inversely age 7 vs 18 4 those normal p <.001). There was an independent association between a low HDL-C concentration and CVD after adjustment for other risk factors (odds ratio [OR]=1.42; 95% CI, 1.26−1.60; P<.001) and with silent target organ damage (OR=1.31; 95% CI, 1.15−1.49; P<.001). Similarly, there was an independent inverse association between the HDL-C concentration (in quintiles) and the prevalence of CVD, particularly for HDL-C concentrations <58 mg dl conclusions one in 4 hypertensive women aged ge 55 years had a low hdl-c concentration which was independently associated with the presence of cvd moreover there an inverse association between and prevalence even at normal concentrations

1885-5857/© 2009 Sociedad Española de Cardiología. Published by Elsevier España, S.L.U. All rights reserved

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