Revista Española de Cardiología (English Edition) Revista Española de Cardiología (English Edition)
Rev Esp Cardiol. 2012;65:152-7 - Vol. 65 Num.02 DOI: 10.1016/j.rec.2011.09.018

Lifestyle Changes Lower FABP4 Plasma Concentration in Patients With Cardiovascular Risk

Iolanda Lázaro a, Raimon Ferré a, Núria Plana a, Gemma Aragonès a, Josefa Girona a, Jordi Merino a, Mercedes Heras a, Anna Cabré a, Lluís Masana a,

a Unitat de Medicina Vascular i Metabolisme, Unitat de Recerca de Lípids i Arteriosclerosi, Departament de Medicina Interna, Hospital Universitari Sant Joan, IISPV, Universitat Rovira i Virgili, and CIBERDEM, Reus, Tarragona, Spain

Keywords

FABP4. Body weight loss. Physical activity.

Abstract

Introduction and objectives

To analyze the impact of lifestyle changes on adipocyte fatty acid-binding protein (FABP4) plasma levels in patients with cardiovascular risk.

Methods

A 1-year prospective study enrolled 140 patients with cardiovascular risk but without previous cardiovascular disease to evaluate the impact of therapeutic lifestyle changes on cardiovascular risk, focusing on tobacco, nutrition education, and physical activity.

Results

The FABP4 variation was inversely associated to physical activity changes (MET·h/wk). FABP4 significantly decreased in patients with increased physical activity, whereas it increased with physical activity reduction. These FABP4 changes were also associated with modifications in body mass index and insulin resistance parameters; however, the correlations between physical activity and FABP4 remained after adjusting for these confounding variables. Changes in physical activity were the main predictors of FABP4 modifications. FABP4 reductions were directly associated with low-density lipoprotein-cholesterol and apolipoprotein B reductions. Neither tobacco cessation nor diet composition modified FABP4 concentrations.

Conclusions

Increasing aerobic physical activity can decrease FABP4 plasma levels, independently of weight reduction. If a causal role of FABP4 in metabolic and vascular alterations could be established, our results would add new positive effects on metabolic and cardiovascular risk of both physical activity and avoiding obesity.

1885-5857/© 2012 Sociedad Española de Cardiología. Published by Elsevier España, S.L.U. All rights reserved

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