Revista Española de Cardiología (English Edition) Revista Española de Cardiología (English Edition)
Rev Esp Cardiol. 2015;68:665-71 - Vol. 68 Num.08 DOI: 10.1016/j.rec.2014.07.035

Long-term Effects of Plant Stanols on the Lipid Profile of Patients With Hypercholesterolemia. A Randomized Clinical Trial

Ignacio Párraga-Martínez a,, Jesús D. López-Torres-Hidalgo b, José M. del Campo-del Campo c, María P. Galdón-Blesa a, Juan C. Precioso-Yáñez a, Joseba Rabanales-Sotos d, Mercedes García-Reyes-Ramos e, Fernando Andrés-Pretel f, Beatriz Navarro-Bravo f, Ángeles Lloret-Callejo g

a Centro de Salud de La Roda, Servicio de Salud de Castilla-La Mancha, La Roda, Albacete, Spain
b Centro de Salud Zona IV, Servicio de Salud de Castilla-La Mancha, Facultad de Medicina de Albacete, Universidad de Castilla-La Mancha, Albacete, Spain
c Centro de Salud de Almansa, Servicio de Salud de Castilla-La Mancha, Albacete, Spain
d Gerencia Atención Integrada de Albacete, Servicio de Salud de Castilla-La Mancha, Albacete, Spain
e Centro de Salud Zona III, Servicio de Salud de Castilla-La Mancha, Albacete, Spain
f Unidad de Apoyo a la Investigación Clínica, Gerencia de Atención Integrada de Albacete, Servicio de Salud de Castilla-La Mancha, Albacete, Spain
g Departamento de Farmacia, Gerencia de Atención Integrada de Albacete, Albacete, Spain

Keywords

Hypercholesterolemia. Phytosterols. Primary health care. Clinical trial.

Abstract

Introduction and objectives

Plant stanol consumption may improve long-term cholesterol control. The aim of the present study was to evaluate the effectiveness of 2 g/day of plant stanols in reducing low-density lipoprotein cholesterol levels in patients with hypercholesterolemia.

Methods

This randomized, double-blind, and placebo-controlled study included 182 adults diagnosed with hypercholesterolemia. A yogurt drink containing 2 g of plant stanols was administered to 91 participants in the intervention group; 91 participants in the control group received unsupplemented yogurt. The primary end point was the change in the lipid profile at 12 months.

Results

Low-density lipoprotein cholesterol levels at 12 months were significantly more reduced in the stanol intervention group than in the control group: 13.7 (95% confidence interval, 3.2-24.1) mg/dL (P = .011). A reduction of more than 10% in low-density lipoprotein cholesterol was achieved by a significantly higher proportion of participants in the intervention group (relative risk = 1.7; 95% confidence interval, 1.1-2.7). In this group, the mean (standard deviation) level of low-density lipoprotein cholesterol decreased by 11.0% (23.9%).

Conclusions

Our results confirm that administration of plant stanols at a dosage of 2 g/day for 12 months significantly reduces (by slightly more than 10%) the concentrations of low-density lipoprotein cholesterol in individuals with hypercholesterolemia.

Trial registration (www.ClinicalTrials.gov): Current Controlled Trials NCT01406106.

1885-5857/© 2015 Sociedad Española de Cardiología. Published by Elsevier España, S.L.U. All rights reserved

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