Revista Española de Cardiología (English Edition) Revista Española de Cardiología (English Edition)
Rev Esp Cardiol. 2014;67:624-31 - Vol. 67 Num.08 DOI: 10.1016/j.rec.2013.10.019

Metabolic and Inflammatory Profiles of Biomarkers in Obesity, Metabolic Syndrome, and Diabetes in a Mediterranean Population. DARIOS Inflammatory Study

Daniel Fernández-Bergés a,b,, Luciano Consuegra-Sánchez a,c, Judith Peñafiel d, Antonio Cabrera de León e,f, Joan Vila d,g, Francisco Javier Félix-Redondo a,h, Antonio Segura-Fragoso i, José Lapetra j,k, María Jesús Guembe l,m, Tomás Vega n, Montse Fitó k,o, Roberto Elosua d, Oscar Díaz o,p, Jaume Marrugat d

a Unidad de Investigación Cardiovascular GRIMEX, Programa de Investigación Cardiovascular (PERICLES), Villanueva de la Serena, Badajoz, Spain
b Hospital Don Benito-Villanueva, Gerencia de Área de Salud Don Benito-Villanueva, Don Benito, Badajoz, Spain
c Servicio de Cardiología, Hospital Universitario de Santa Lucía, Cartagena, Murcia, Spain
d Grupo de Epidemiología y Genética Cardiovascular, Programa de Investigación en Procesos Inflamatorios y Cardiovasculares, IMIM-Institut Hospital del Mar d’Investigacions Mèdiques, Barcelona, Spain
e Unidad de Investigación de Atención Primaria y del Hospital Universitario Nuestra Señora de Candelaria, Santa Cruz de Tenerife, Spain
f Área de Medicina Preventiva y Salud Pública, Universidad de La Laguna, La Laguna, Santa Cruz de Tenerife, Spain
g CIBER de Epidemiología y Salud Pública, Barcelona, Spain
h Centro de Salud Villanueva Norte, Villanueva de la Serena, Badajoz, Spain
i Instituto de Ciencias de la Salud de Castilla-La Mancha, Talavera de la Reina, Toledo, Spain
j Centro de Salud Universitario San Pablo, Distrito Sanitario de Atención Primaria Sevilla, Servicio Andaluz de Salud, Seville, Spain
k CIBER de Fisiopatología de la Obesidad y Nutrición (CIBERobn), Instituto de Salud Carlos III, Spain
l Servicio de Investigación, Innovación y Formación Sanitaria, Departamento de Salud, Gobierno de Navarra, Pamplona, Navarra, Spain
m Grupo de Investigación Riesgo Vascular en Navarra (RIVANA), Spain
n Dirección General de Salud Pública, Consejería de Sanidad, Junta de Castilla y León, Valladolid, Spain
o Grupo de Riesgo Cardiovascular y Nutrición, Programa de Investigación en Procesos Inflamatorios y Cardiovasculares, IMIM-Institut Hospital del Mar d’Investigacions Mèdiques, Barcelona, Spain
p Programa de Doctorat en Biomedicina, Departament de Ciències Experimentals i de la Salut, Universitat Pompeu Fabra, Barcelona, Spain

Keywords

Biomarkers. Metabolic syndrome. Obesity. Diabetes mellitus.

Abstract

Introduction and objectives

There is a paucity of data regarding the differences in the biomarker profiles of patients with obesity, metabolic syndrome, and diabetes mellitus as compared to a healthy, normal weight population. We aimed to study the biomarker profile of the metabolic risk continuum defined by the transition from normal weight to obesity, metabolic syndrome, and diabetes mellitus.

Methods

We performed a pooled analysis of data from 7 cross-sectional Spanish population-based surveys. An extensive panel comprising 20 biomarkers related to carbohydrate metabolism, lipids, inflammation, coagulation, oxidation, hemodynamics, and myocardial damage was analyzed. We employed age- and sex-adjusted multinomial logistic regression models for the identification of those biomarkers associated with the metabolic risk continuum phenotypes: obesity, metabolic syndrome, and diabetes mellitus.

Results

A total of 2851 subjects were included for analyses. The mean age was 57.4 (8.8) years, 1269 were men (44.5%), and 464 participants were obese, 443 had metabolic syndrome, 473 had diabetes mellitus, and 1471 had a normal weight (healthy individuals). High-sensitivity C-reactive protein, apolipoprotein B100, leptin, and insulin were positively associated with at least one of the phenotypes of interest. Apolipoprotein A1 and adiponectin were negatively associated.

Conclusions

There are differences between the population with normal weight and that having metabolic syndrome or diabetes with respect to certain biomarkers related to the metabolic, inflammatory, and lipid profiles. The results of this study support the relevance of these mechanisms in the metabolic risk continuum. When metabolic syndrome and diabetes mellitus are compared, these differences are less marked.

1885-5857/© 2014 Sociedad Española de Cardiología. Published by Elsevier España, S.L.U. All rights reserved

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