Revista Española de Cardiología (English Edition) Revista Española de Cardiología (English Edition)
Rev Esp Cardiol. 2012;65:241-8 - Vol. 65 Num.03 DOI: 10.1016/j.rec.2011.10.017

Metabolic Syndrome in Spain: Prevalence and Coronary Risk Associated With Harmonized Definition and WHO Proposal. DARIOS Study

Daniel Fernández-Bergés a,, Antonio Cabrera de León b,c, Héctor Sanz d, Roberto Elosua d,e, María J. Guembe f,g, Maite Alzamora h,i, Tomás Vega-Alonso j, Francisco J. Félix-Redondo a,k, Honorato Ortiz-Marrón l, Fernando Rigo m, Carmen Lama n,o, Diana Gavrila e,p, Antonio Segura-Fragoso q, Luis Lozano a, Jaume Marrugat d

a Unidad de Investigación Don Benito Villanueva, Programa de Investigación en Enfermedades Cardiovasculares (PERICLES), Fundesalud, Gerencia Área Sanitaria Don Benito-Villanueva, Badajoz, Spain
b Unidad de Investigación de Atención Primaria, Hospital Universitario Nuestra Señora de Candelaria, Santa Cruz de Tenerife, Spain
c Área de Medicina Preventiva y Salud Pública, Universidad de La Laguna, La Laguna, Santa Cruz de Tenerife, Spain
d Grupo de Epidemiología y Genética Cardiovascular, Programa de Investigación en Procesos Inflamatorios y Cardiovasculares, Instituto Municipal de Investigación Médica, Barcelona, Spain
e CIBER Epidemiología y Salud Pública (CIBERESP), Spain
f Servicio de Docencia y Desarrollo Sanitarios, Departamento de Salud, Gobierno de Navarra, Pamplona, Navarra, Spain
g Grupo de Investigación Riesgo Vascular en Navarra (RIVANA), Departamento de Salud, Gobierno de Navarra, Pamplona, Navarra, Spain
h Centre de Salud Riu Nord-Riu Sud, Institut Català de la Salut, Santa Coloma de Gramenet, Barcelona, Spain
i USR Metropolitana Nord, ICS-IDIAP Jordi Gol, Mataró, Barcelona, Spain
j Dirección General de Salud Pública e Investigación, Desarrollo e Innovación, Consejería de Sanidad de la Junta de Castilla y León, Valladolid, Spain
k Centro de Salud Villanueva Norte, Servicio Extremeño de Salud, Villanueva de la Serena, Badajoz, Spain
l Servicio de Epidemiología, Subdirección General de Promoción de la Salud y Prevención, Servicio Madrileño de Salud, Madrid, Spain
m Grupo Cardiovascular de Baleares de redIAPP, UB Genova, IB-Salut, Palma de Mallorca, Baleares, Spain
n Gestión y Evaluación, Dirección General de Asistencia Sanitaria, Servicio Andaluz de Salud, Spain
o CIBER de Fisiopatología de la Obesidad y la Nutrición, Instituto de Salud Carlos III, Madrid, Spain
p Servicio de Epidemiología, Consejería de Sanidad y Consumo de la Región de Murcia, Murcia, Spain
q Servicio de Investigación, Instituto de Ciencias de la Salud de Castilla-La Mancha, Talavera de la Reina, Toledo, Spain

Keywords

Metabolic syndrome. Diabetes mellitus. Cardiovascular disease. Risk scores.

Abstract

Introduction and objectives

To update the prevalence of metabolic syndrome and associated coronary risk in Spain, using the harmonized definition and the new World Health Organization proposal (metabolic premorbid syndrome), which excludes diabetes mellitus and cardiovascular disease.

Methods

Individual data pooled analysis study of 24 670 individuals from 10 autonomous communities aged 35 to 74 years. Coronary risk was estimated using the REGICOR function.

Results

Prevalence of metabolic syndrome was 31% (women 29% [95% confidence interval, 25%-33%], men 32% [95% confidence interval, 29%-35%]). High blood glucose (P=.019) and triglycerides (P<.001) were more frequent in men with metabolic syndrome, but abdominal obesity (P<.001) and low high-density lipoprotein cholesterol (P=.001) predominated in women. Individuals with metabolic syndrome showed moderate coronary risk (8% men, 5% women), although values were higher (P<.001) than in the population without the syndrome (4% men, 2% women). Women and men with metabolic syndrome had 2.5 and 2 times higher levels of coronary risk, respectively (P<.001). Prevalence of metabolic premorbid syndrome was 24% and the increase in coronary risk was also proportionately larger in women than in men (2 vs 1.5, respectively; P<.001).

Conclusions

Prevalence of metabolic syndrome is 31%; metabolic premorbid syndrome lowers this prevalence to 24% and delimits the population for primary prevention. The increase in coronary risk is proportionally larger in women, in both metabolic syndrome and metabolic premorbid syndrome.

1885-5857/© 2012 Sociedad Española de Cardiología. Published by Elsevier España, S.L.U. All rights reserved

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