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Revista Española de Cardiología (English Edition) Revista Española de Cardiología (English Edition)

Epigenetic Biomarkers and Cardiovascular Disease: Circulating MicroRNAs

David de Gonzalo-Calvo a,b,, Eduardo Iglesias-Gutiérrez c, Vicenta Llorente-Cortés a,b,d

a Grupo de Lípidos y Patología Cardiovascular, Instituto de Investigación Biomédica Sant Pau (IIB Sant Pau), Barcelona, Spain
b Centro de Investigación Biomédica en Red de Enfermedades Cardiovasculares (CIBERCV), Instituto de Salud Carlos III, Madrid, Spain
c Departamento de Biología Funcional (Área de Fisiología), Universidad de Oviedo, Asturias, Spain
d Instituto de Investigaciones Biomédicas de Barcelona (IibB), Consejo Superior de Investigaciones Científicas (CSIC), Barcelona, Spain

Refers to

The State of Cardiovascular Genomics: Abundant Data, Limited Information
Stella Aslibekyan, Edward A. Ruiz-Narváez
Rev Esp Cardiol. 2017;70:696-8
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Keywords

MicroRNA. Cardiovascular disease. Biomarkers.

Abstract

MicroRNAs (miRNAs) are a class of small noncoding RNA (20-25 nucleotides) involved in gene regulation. In recent years, miRNAs have emerged as a key epigenetic mechanism in the development and physiology of the cardiovascular system. These molecular species regulate basic functions in virtually all cell types, and are therefore directly associated with the pathophysiology of a large number of cardiovascular diseases. Since their relatively recent discovery in extracellular fluids, miRNAs have been studied as potential biomarkers of disease. A wide array of studies have proposed miRNAs as circulating biomarkers of different cardiovascular pathologies (eg, myocardial infarction, coronary heart disease, and heart failure, among others), which may have superior physicochemical and biochemical properties than the conventional protein indicators currently used in clinical practice. In the present review, we provide a brief introduction to the field of miRNAs, paying special attention to their potential clinical application. This includes their possible role as new diagnostic or prognostic biomarkers in cardiovascular disease.

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1885-5857/© 2017 Sociedad Española de Cardiología. Published by Elsevier España, S.L.U. All rights reserved