Revista Española de Cardiología (English Edition) Revista Española de Cardiología (English Edition)
Rev Esp Cardiol. 2007;60:1035-41 - Vol. 60 Num.10

Prognostic Value of ECGs in Patients With Type-2 Diabetes Mellitus Without Known Cardiovascular Disease

Ana de Santiago a, Alberto García-Lledó b, Esther Ramos c, Catalina Santiago c

a Instituto Madrileño de la Salud, Área III, Madrid, Spain. Departamento de Medicina, Universidad de Alcalá, Alcalá de Henares, Madrid, Spain
b Departamento de Medicina, Universidad de Alcalá, Alcalá de Henares, Madrid, Spain. Servicio de Cardiología, Hospital Universitario de Guadalajara, SESCAM, Guadalajara, Spain
c Instituto Madrileño de la Salud, Área III, Madrid, Spain

Keywords

Diabetes mellitus. Prognosis. Electrocardiography.

Abstract

Introduction and objectives. The predictive value of ECG abnormalities in patients with type-2 diabetes mellitus (DM2) has not been fully studied. Our objective was to assess the prognostic value of ECG abnormalities in patients with DM2 but without known cardiovascular disease. Methods. Overall, 412 patients with DM2 were identified at two primary care centers in the same city. Two hundred and tiwenty one patients younger 80 years without known cardiovascular disease were included in the study. An ECG was recorded at baseline and annually during follow-up. The ECGs were evaluated using a system based on the Minnesota code. The main study end-point during follow-up was the occurrence of a cardiovascular event, as defined in the Framingham study. Results. The mean follow-up duration was 5.9 years (1.1­8.5 years). At the beginning of the study, 24.9% of patients had ECG abnormalities; at the end, 44.3% had abnormalities. Cardiovascular events occurred in 65 patients (29.4%). The relative risk (RR) of a cardiovascular event in a patient with an ECG abnormality was 8.28 (95% confidence interval [CI], 3.36­20.42). Only hypertension (RR = 2.29; 95% CI, 1.24­4.22) and age were significantly related to the occurrence of a cardiovascular event. Multiple regression analysis that included classical risk factors and ECG findings showed that an ECG abnormality was a significant independent predictor, with adjusted RR = 5.95 (95% CI, 2.29­15.47). Conclusions. The presence of an ECG abnormality can predict the occurrence of a future cardiovascular event in patients with DM2 more accurately than risk factors alone. This finding could be helpful in selecting subgroups of high-risk diabetic patients.

1885-5857/© 2007 Sociedad Española de Cardiología. Published by Elsevier España, S.L.U. All rights reserved

Cookies
x
To improve our services and products, we use cookies (own or third parties authorized) to show advertising related to client preferences through the analyses of navigation customer behavior. Continuing navigation will be considered as acceptance of this use. You can change the settings or obtain more information by clicking here.
Cookies policy
x
To improve our services and products, we use cookies (own or third parties authorized) to show advertising related to client preferences through the analyses of navigation customer behavior. Continuing navigation will be considered as acceptance of this use. You can change the settings or obtain more information by clicking here.