Revista Española de Cardiología (English Edition) Revista Española de Cardiología (English Edition)
Rev Esp Cardiol. 2007;60:1051-8 - Vol. 60 Num.10

Relationship of C-Reactive Protein to Adiposity, Cardiovascular Risk Factors and Subclinical Atherosclerosis in Healthy Children

Mónica Acevedo a, Pilar Arnáiz b, Salesa Barja c, Claudia Bambs a, Ximena Berríos d, Beatriz Guzmán d, Jacqueline Carvajal a, Berta Cassis c, Carlos Navarrete a

a Departamento de Enfermedades Cardiovasculares, Facultad de Medicina, Pontificia Universidad Católica de Chile, Santiago, Chile
b Departamento de Enfermedades Cardiovasculares, Facultad de Medicina, Pontificia Universidad Católica de Chile, Santiago, Chile. Departamento de Pediatría, Facultad de Medicina, Pontificia Universidad Católica de Chile, Santiago, Chile
c Departamento de Pediatría, Facultad de Medicina, Pontificia Universidad Católica de Chile, Santiago, Chile
d Departamento de Salud Pública, Facultad de Medicina, Pontificia Universidad Católica de Chile, Santiago, Chile

Keywords

C-reactive protein. Risk factors. Adiposity. Children. Obesity.

Abstract

Introduction and objectives. In adults, C-reactive protein is a marker of cardiovascular risk. It is associated with both classical and metabolic risk factors and is a predictor of cardiovascular events. The aim was to investigate the relationship of the C-reactive protein concentration to classical cardiovascular risk factors, measures of adiposity subclinical atherosclerosis in children. Methods. The values of traditional risk factors, anthropometric parameters, fasting lipids, glucose and C-reactive protein levels were recorded. In addition, the carotid artery intima-media thickness was measured, and brachial artery endothelial function was assessed using flow-mediated dilation. Results. The study included 112 children (58 male) with a mean age of 11.3±1.9 years. The mean C-reactive protein concentration was 0.9±1.5 mg/L. In males, there were significant direct correlations between the C-reactive protein concentration and body mass index, total fat mass, central adiposity, waist circumference, and low-density lipoprotein (LDL) cholesterol level. In females, C-reactive protein was associated with only body mass index. Boys in the highest C-reactive protein tertile had a significantly higher body mass index, total fat mass, LDL cholesterol level, and waist circumference. In the whole group, the best predictor of an elevated ultrasensitive C-reactive protein concentration was the body mass index (odds ratio=2.04 [1.30­3.21]). No relationship was found between the C-reactive protein concentration and the percentage flow-mediated dilation of the brachial artery or the carotid intima-media thickness. Conclusions. The results indicate that, in children, there is a significant direct relationship between the ultrasensitive C-reactive protein concentration and measures of adiposity, particularly body mass index. However, no relationship between C-reactive protein and subclinical atherosclerosis was observed.

1885-5857/© 2007 Sociedad Española de Cardiología. Published by Elsevier España, S.L.U. All rights reserved

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