Revista Española de Cardiología (English Edition) Revista Española de Cardiología (English Edition)
Rev Esp Cardiol. 2010;63:170-80 - Vol. 63 Num.02 DOI: 10.1016/S1885-5857(10)70035-9

Sex Does Not Influence Prognosis in Diabetic Patients. The Barbanza Diabetes Study

Rafael Vidal-Pérez a, Fernando Otero-Raviña b, Lilian Grigorian-Shamagian a, Vicente Parga-García c, María J. Eirís-Cambre d, Concepción de Frutos-de Marcos e, Carmen Caneda-Villar f, Rosa de la Fuente-Mariño g, Ana Ramos-González h, José R. González-Juanatey a, for the Barbanza Group

a Servicio de Cardiología, Hospital Clínico Universitario de Santiago, Santiago de Compostela, A Coruña, Spain
b Sección de Coordinación Asistencial, SERGAS, Santiago de Compostela, A Coruña, Spain
c Centro de Salud, Ribeira, A Coruña, Spain
d Centro de Salud, Muros, A Coruña, Spain
e Centro de Salud, Padrón, A Coruña, Spain
f Centro de Salud, Rois, A Coruña, Spain
g Centro de Salud, Rianxo, A Coruña, Spain
h Centro de Salud Federico Tapia, A Coruña, Spain.

Keywords

Diabetes mellitus. Sex. Prognosis. Primary care. Ischemic heart disease.

Abstract

Introduction and objectives. To determine the influence of sex on cardiovascular complications in diabetic patients. Methods. This multicenter prospective cohort study involved 1423 consecutive patients with diabetes mellitus who were recruited during consultations with 31 primary care physicians. The patients’ characteristics were recorded and they were followed up for 45±10 months. Results. The mean age of the patients (50% female) was 66 years, 64% had hypertension, 70% had dyslipidemia, and 26% had had a previous cardiovascular event. Cardiovascular disease, predominantly ischemic heart disease, was observed more frequently in men and a higher percentage had end-organ damage (57.7% of males versus 45.4% of females; P < .0001). Women had poorer glycemic control, higher total cholesterol levels and lower high-density lipoprotein cholesterol levels. By the end of follow-up, 81 patients had died (5.7% of males versus 6.7% of females; P=.513). There were no sex differences in cardiovascular complications during follow up (15.8% in males versus 13.7% in females; P=.368). Multivariate analysis identified the following factors as independent predictors of morbidity or mortality: age (hazard ratio [HR]=1.04; 95% confidence interval [CI], 1.02-1.06), existing cardiovascular disease (HR=1.96; 95% CI, 1.38-2.79), diuretic treatment (HR=1.62; 95% CI, 1.10-2.38), and albuminuria (HR=1.86; 95% CI, 1.33-2.61). Conclusions. No difference was observed in mediumterm prognosis, with regard to mortality and cardiovascular selecmorbidity, between male and female diabetics from the same geographical area, despite the presence of clinical differences between the sexes.

1885-5857/© 2010 Sociedad Española de Cardiología. Published by Elsevier España, S.L.U. All rights reserved

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