Revista Española de Cardiología (English Edition) Revista Española de Cardiología (English Edition)
Rev Esp Cardiol. 2009;62(10):1134-40 - Vol. 62 Num.10 DOI: 10.1016/S1885-5857(09)73328-6

The REGICOR-Calibrated Function Provides a Better Classification of High-Risk Patients on Statin Treatment in the Spanish Population Than the Framingham or SCORE Classifications

José M. Baena-Díez a, María Grau b, Ricard Sánchez-Pérez c, Eva Altes-Vaques c, Luis H. Salas-Gaetjens c, María R. Hernández-Ibáñez c

a Centro de Salud La Marina, Institut Català de la Salut, Barcelona, Spain. IDIAP/Fundación Jordi Gol i Gurina, Institut Català de la Salut, Barcelona, Spain. Grupo de Epidemiología y Genética Cardiovascular (ULEC-EGEC), Programa de Investigación en Procesos Inflamatorios y Cardiovasculares, Instituto Municipal de Investigación Médica, IMIM-Hospital del Mar, Barcelona, Spain
b Grupo de Epidemiología y Genética Cardiovascular (ULEC-EGEC), Programa de Investigación en Procesos Inflamatorios y Cardiovasculares, Instituto Municipal de Investigación Médica, IMIM-Hospital del Mar, Barcelona, Spain
c Centro de Salud La Marina, Institut Català de la Salut, Barcelona, Spain

Keywords

Statins. Primary prevention. Cardiovascular risk factors. Coronary heart disease risk functions.

Abstract

Introduction and objectives. To determine which cardiovascular risk function is best for classifying high-risk individuals on statins. Methods. Descriptive cross-sectional study of 804 randomly selected patients aged 35-74 years. Variables studied included statin treatment, high cardiovascular risk according to Framingham-REGICOR (10-year risk ≥10%), Framingham-Wilson (10-year risk ≥20%) and SCORE (10-year risk ≥5%) functions, age, sex, cardiovascular risk factors, and total and high-density lipoprotein (HDL) cholesterol. Results. Overall, 83 patients (10.3%) were taking statins. The prevalence of hypercholesterolemia was 25.6%. When high-risk patients were compared with low- and medium-risk patients, the SCORE function only found a significant difference in HDL-cholesterol level (difference, 5.1 mg/dl; P < .001), whereas the Framingham-REGICOR and Framingham-Wilson functions showed that hypercholesterolemia was more prevalent (at 41% and 37.8%, respectively), the total cholesterol level was higher (difference, 15 mg/dl and 12.5 mg/dl, respectively), and the HDL-cholesterol level was lower (difference, 11.9 mg/ dl and 12 mg/dl, respectively; all P < .001). The percentage of patients on statins classified as high-risk by each function was 16% for Framingham-REGICOR (odds ratio [OR]=1.81; 95% confidence interval [CI], 1.01-3.27), 13.4% for Framingham-Wilson (OR=1.47; 95% CI, 0.87-2.47) and 10.6% for SCORE (OR=1.09; 95% CI, 0.50-2.37). Statin use was also significantly associated with hypertension (OR=1.89; 95% CI, 1.20-2.99) and hypercholesterolemia (OR=11.01; 95% CI, 6.55-18.53), and inversely associated with age in patients <65 years or 95 ci 0 32-0 81 conclusions the framingham-regicor function was better at classifying high-risk patients on statins than framingham-wilson score functions statin use associated with hypercholesterolemia and hypertension inversely age in <65 years

1885-5857/© 2009 Sociedad Española de Cardiología. Published by Elsevier España, S.L.U. All rights reserved

Cookies
x
To improve our services and products, we use cookies (own or third parties authorized) to show advertising related to client preferences through the analyses of navigation customer behavior. Continuing navigation will be considered as acceptance of this use. You can change the settings or obtain more information by clicking here.
Cookies policy
x
To improve our services and products, we use cookies (own or third parties authorized) to show advertising related to client preferences through the analyses of navigation customer behavior. Continuing navigation will be considered as acceptance of this use. You can change the settings or obtain more information by clicking here.