Resumen
En los últimos años se han descubierto nuevos aspectos fisiológicos del sistema renina-angiotensina que podrían producir cambios en las estrategias terapéuticas seguidas hasta ahora para conseguir su inhibición. Especialmente, el descubrimiento de la existencia de un sistema renina-angiotensina intracelular funcional ha permitido comprender muchos aspectos de la fisiopatología del remodelado cardiaco y puede ayudar a explicar la eficacia sólo parcial de los inhibidores de la enzima de conversión de la angiotensina y de los bloqueadores del receptor de angiotensina, así como la superioridad de los inhibidores directos de la renina, en determinadas condiciones patológicas asociadas con la enfermedad cardiovascular.
Palabras clave
Renina
Aliskiren
Intracelular
Angiotensina II
Cardiomiocitos
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