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Vol. 6. Núm. D.
Utilidad terapéutica de los ácidos grasos omega-3
Páginas 38D-51D (Junio 2006)
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Vol. 6. Núm. D.
Utilidad terapéutica de los ácidos grasos omega-3
Páginas 38D-51D (Junio 2006)
Utilidad terapéutica de los ácidos grasos omega-3
Acceso a texto completo
Supresión de arritmias supraventriculares y ventriculares. ¿Qué papel pueden desempeñar los ácidos grasos omega-3?
Suppression of Supraventricular and Ventricular Arrhythmias. What is the Role of Omega-3 Fatty Acids?
Visitas
...
Ramón Bover??
Autor para correspondencia
ramonbover@yahoo.es

Correspondencia: Dr. R. Bover. Servicio de Cardiología. Hospital Clínico Universitario San Carlos. Profesor Martín Lagos, s/n. 28040 Madrid. España.
, Julián Villacastín, Nicasio Pérez-Castellano, Javier Moreno, Ricardo Morales, Carlos Macaya
Unidad de Arritmias. Instituto Cardiovascular. Hospital Clínico San Carlos. Madrid. España
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Los ácidos grasos poliinsaturados n-3 u omega-3 son una prometedora terapia dietética preventiva para la enfermedad cardiovascular, y constituyen un método seguro y efectivo para la prevención de la muerte súbita. El pescado graso es la fuente dietética principal de ácidos grasos poliinsaturados n-3. En los últimos años, las propiedades antiarrítmicas de estos ácidos grasos han sido extensamente investigadas. Se han propuesto y estudiado varios mecanismos para explicar este efecto antiarrítmico, pero hasta el momento ninguno de ellos ha sido validado de forma definitiva. En esta revisión se resumen los conocimientos epidemiológicos que sostienen el uso de los ácidos grasos n-3 con esta indicación, la evidencia básica y clínica alcanzada en estudios experimentales en animales y humanos, así como las teorías actuales sobre el mecanismo antiarrítmico de esta clase de ácidos grasos poliinsaturados.

Palabras clave:
Aceite de pescado
Ácidos grasos n-3
Arritmia
Muerte súbita cardiaca
Electrofisiología

Dietary n-3 or omega-3 polyunsaturated fatty acids show promise as preventive therapy for cardiovascular disease, offering a safe and effective means of reducing sudden death. Oily fish is the main dietary source of omega-3 polyunsaturated fatty acid. In recent years, the anti-arrhythmic effects of polyunsaturated fatty acids have been extensively investigated. Several mechanisms that could explain these antiarrhythmic effects have been proposed and have been investigated. However, to date, no definitive mechanism has been identified. This review summarizes the epidemiological data supporting the use of omega-3 fatty acids in this context, the preclinical and clinical evidence revealed by animal and human studies, and current hypotheses about the antiarrhythmic mechanism of this class of polyunsaturated fatty acid.

Key words:
Fish oil
Omega-3 fatty acids
Arrhythmia
Sudden cardiac death
Electrophysiology
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