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Vol. 54. Núm. 5.
Páginas 635-642 (Mayo 2001)
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Vol. 54. Núm. 5.
Páginas 635-642 (Mayo 2001)
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Temas actuales en biología vascular: puesta al día para el siglo Xxi
Current Topics in Vascular Biology: an Update for the 21st Century
Cam Pattersona
a Department of Internal Medicine, and Lineberger Comprehensive Cancer Center. University of North Carolina at Chapel Hill. Chapel Hill. North Carolina. EE.UU.
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Figuras (1)
Aunque se da por sentado que los vasos sanguíneos desempeñan un papel primordial en la regulación del sistema cardiovascular en condiciones fisiológicas y patológicas, el mecanismo por el que lo hacen no ha sido comprendido hasta las últimas décadas. El campo de la biología vascular nació de esta apreciación de la primacía de los vasos sanguíneos en la patología cardiovascular. En esta revisión actualizamos varios temas de particular interés en el campo de la biología vascular del siglo xxi: principalmente el papel del estrés oxidativo en la función y la disfunción vascular; la angiogénesis y las terapias génicas angiogénicas, y los biomarcadores emergentes de aterosclerosis. Es probable que cada una de estas áreas experimente avances significativos en los años venideros que tendrán un impacto clínico directo sobre la toma de decisiones y el cuidado de los pacientes con enfermedades cardiovasculares.
Palabras clave:
Biología vascular
Estrés oxidativo
Terapia génica
Although taken for granted in the present day, the central role played by the blood vessels themselves in regulating the cardiovascular system under physiologic and pathologic conditions has only been understood in the last several decades. The field of vascular biology grew out of this appreciation of the primacy of the vasculature in cardiovascular pathologies. In this review, we come up to date on several topics of particular interest to the field of vascular biology as it enters the 21 st century: namely, the role of oxidative stress in vascular function and dysfunction; angiogenesis and angiogenic gene therapies; and emerging biomarkers of atherosclerosis. Each of these areas is likely to experience significant advances in the coming years that will directly impact clinical decision-making and care of patients with cardiovascular diseases.
Vascular biology
Oxidative stress
Angiogenic gene therapy
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