Publish in this journal
Journal Information
Vol. 67. Issue 2.
Pages 101-106 (February 2014)
Not available
Vol. 67. Issue 2.
Pages 101-106 (February 2014)
Original article
Full text access
Prognostic Value of Body Mass Index and Waist Circumference in Patients With Chronic Heart Failure (Spanish REDINSCOR Registry)
Valor pronóstico del índice de masa corporal y el perímetro de cintura en los pacientes con insuficiencia cardiaca crónica (Registro Español REDINSCOR)
Teresa Puiga,
Corresponding author

Corresponding author. Servicio de Epidemiología Clínica, Hospital de la Santa Creu i Sant Pau, Universitat Autonòma de Barcelona, St. Antoni M. Claret 167, 08025 Barcelona, Spain.
, Andreu Ferrero-Gregorib, Eulalia Roigb, Rafael Vazquezc, Jose R. Gonzalez-Juanateyd, Domingo Pascual-Figale, Juan Delgadof, Luis Alonso-Pulpong, Xavier Borrasb, Ana Mendezb, Juan Cincab, on behalf of the REDINSCOR researchers
a Servicio de Epidemiología Clínica, Hospital de la Santa Creu i Sant Pau, IIb-Sant Pau, Universitat Autònoma de Barcelona, Barcelona, Spain
b Servicio de Cardiología, Hospital de la Santa Creu i Sant Pau, IIb-Sant Pau, Universitat Autònoma de Barcelona, Barcelona, Spain
c Servicio de Cardiología, Hospital Puerta del Mar, Cádiz, Spain
d Servicio de Cardiología, Hospital Clínico, Santiago de Compostela, A Coruña, Spain
e Servicio de Cardiología, Hospital Virgen de la Arrixaca, El Palmar, Murcia, Spain
f Servicio de Cardiología, Hospital 12 de Octubre, Madrid, Spain
g Servicio de Cardiología, Hospital Puerta de Hierro, Majadahonda, Madrid, Spain
This item has received
Article information
Full Text
Download PDF
Tables (2)
Table 1. Baseline Characteristics of Patients According to Body Mass Index and Central Obesity
Table 2. Cox Proportional Hazard Modelling
Show moreShow less
Additional material (1)
Introduction and objectives

To analyze the association between higher body mass index and waist circumference, and the prognostic values of both indicators in total and cardiac mortality in patients with chronic heart failure.


The study included 2254 patients who were followed up for 4 years. Obesity was classified as a body mass index ≥30 and overweight as a body mass index of 25.0-29.9. Central obesity was defined as waist circumference ≥88 cm for women and ≥102cm for men. Independent predictors of total and cardiac mortality were assessed in a multivariate Cox model adjusted for confounding variables.


Obesity was present in 35% of patients, overweight in 43%, and central obesity in 60%. Body mass index and waist circumference were independent predictors of lower total mortality: hazard ratio=0.84 (P<.001) and hazard ratio=0.97 (P=.01), respectively, and lower cardiac death (body mass index, hazard ratio=0.84, P<.001; waist circumference, hazard ratio=0.97, P=.01). The interaction between body mass index and waist circumference (hazard ratio=1.001, P<.01) showed that the protective effect of body mass index was lost in patients with a waist circumference >120cm.


Mortality was significantly lower in patients with a high body mass index and waist circumference. The results also showed that this protection was lost when these indicators over a certain limit.

Heart failure
Body mass index
Waist circumference
Obesity paradox
Multicenter study
Introducción y objetivos

Analizar la asociación entre el incremento del índice de masa corporal y el perímetro cintura, así como el valor pronóstico de ambos indicadores en la mortalidad total y cardiaca en pacientes con insuficiencia cardiaca crónica.


El estudio incluyó a 2.254 pacientes seguidos durante 4 años. La obesidad se clasificó como índice de masa corporal ≥30 y el sobrepeso, como índice de masa corporal 25,0-29,9; la obesidad central, como perímetro cintura ≥88cm en mujeres y ≥102cm en varones. Los predictores independientes de mortalidad total y cardiaca se evaluaron mediante un modelo multivariable de Cox ajustado por variables de confusión.


Presentó obesidad el 35% de los pacientes; sobrepeso, el 43% y obesidad central, el 60%. El índice de masa corporal y el perímetro de cintura fueron predictores independientes de menor mortalidad total —hazard ratio=0,84 (p<0,001) y hazard ratio=0,97 (p=0,01) respectivamente— y menos muerte cardiaca (índice de masa corporal, hazard ratio=0,84; p<0,001; perímetro de cintura, hazard ratio=0,97; p=0,01). La interacción entre el índice de masa corporal y el perímetro cintura (hazard ratio=1,001; p<0,01) mostró que el efecto protector del índice de masa corporal desaparecía cuando los pacientes tenían un perímetro cintura >120cm.


Se confirma una mortalidad significativamente menor entre los pacientes que presentan un incremento del índice de masa corporal y del perímetro de cintura. Los resultados muestran además que esta protección desaparece al alcanzar valores elevados.

Palabras clave:
Insuficiencia cardiaca
Índice de masa corporal
Perímetro de cintura
Paradoja de la obesidad
Estudio multicéntrico
Full Text


Obesity is an important public health issue that is reaching epidemic proportions in developed and developing countries. According to the World Health Organization, more than 1400 million adults were overweight in 2008; within this group, obesity affected more than 200 million men and nearly 300 million women.1 Obesity itself is considered a chronic disease but it is also an important risk factor for cardiovascular disease. Numerous studies have shown that central obesity—measured by waist circumference (WC)—is associated with greater risk of cardiovascular disease.2–4

The role of obesity in mortality from heart failure (HF) has become controversial with the description of the so-called obesity paradox, which suggests that overweight or obese patients have a better prognosis, despite higher cardiovascular risk. In contrast, cardiac cachexia is associated with higher mortality. Although the mechanisms by which the prognosis of obese patients improves remain unknown, some studies indicate that improvement may be related to the ratio of lean mass to adipose mass, or that measuring nutritional parameters could be more important in determining the relationship between obesity and a lower risk of death.5,6 Central obesity also seems to have a predictive effect in patients with HF,7 although studies of the issue are scarce. In addition, it is unknown whether the protective effect is lost above a certain degree of central obesity.

The main aim of this study was to analyze the association between a higher body mass index (BMI) and WC, and the prognostic value of both indicators for total and cardiac mortality in patients with chronic HF hospitalized in cardiology units in Spanish hospitals.


We enrolled patients on the REDINSCOR (Spanish Heart Failure Network, Red Española de Insuficiencia Cardiaca) registry, a prospective observational study conducted in the HF units of 18 Spanish hospitals. The protocol was approved by the research committees of participating institutions and all patients gave written informed consent.

Patients were included in the study between 2007 and 2011 assuming they met the following criteria: age ≥18 years, symptomatic HF (New York Heart Association functional class II-IV), >24h prior hospitalization for HF in the previous year, being under optimized treatment regimens in line with established clinical practice guidelines,8 and having any of the following echocardiographic abnormalities: ≤40% left ventricular ejection fraction, ≥60mm end-of-diastole diameter, abnormal ventricular relaxation typical of diastolic dysfunction, and ≥14mm interventricular septum and/or posterior wall thickness. We excluded patients with reversible new-onset acute HF and severe valvular disease susceptible to surgical repair, right HF secondary to chronic cor pulmonale or congenital heart disease and/or a concomitant terminal disease.


The data collection questionnaires were specially designed for the study and data was gathered when registering patients on a web site.9 We performed monthly quality control checks during follow-up and data inclusion.

Information on the main risk factors was recorded at the start of the study, during the first outpatient visit following hospitalization. The independent variables recorded were age, sex, high blood pressure (defined as systolic blood pressure ≥140mmHg/diastolic blood pressure ≥90mmHg with or without drug treatment), weight, height, BMI (normal, <25; overweight, 25.0-29.9; obese, ≥30), central obesity (WC ≥88cm in women and ≥102cm in men), diabetes mellitus (defined as a history of criteria of diabetes mellitus or the need for medication), dyslipidemia (history of criteria of dyslipidemia or the need for medication), smoking (“smoker”, 1 or more cigarettes per day; “ex-smoker”, no cigarettes in the last 6 months), history of alcoholism (yes/no), anemia (hemoglobin <120g/L in women and <130g/L in men) and prescription of medication.

Information on the dependent variable of mortality was obtained from medical records and family members. We collected data on total and cardiac mortality. Cardiac mortality included mortality from sudden death, refractory HF, and myocardial infarction. Patients who underwent urgent heart transplantation were classified as death from refractory HF. In all patients, the researcher had to provide details about the death episode. All deaths were reviewed by a mortality committee to validate the cause. Patients lost during follow-up and those undergoing elective heart transplantation were censored.

Statistical Analysis

Continuous variables are expressed as mean (standard deviation) or median [interquartile range], as appropriate. Categorical variables are presented as percentages. We conducted a descriptive analysis, chi-squared and McNemar's tests for categorical variables. To compare continuous variables, we used analysis of variance (ANOVA) and Student's t test for independent related samples.

Multivariate analysis was conducted using Cox proportional hazard modelling. The variables that were significant in the univariate model (P<.1) were included in the multivariate model and the backward stepwise method was used to identify independent risk factors. We also studied the interaction between BMI and WC. We determined the adjustment of the model with clinically relevant variables. The proportionality assumption of the Cox model hazard ratio (HR) was determined using Schoenfeld residuals. The discrimination of the model was calculated with Harrell's C-index, and calibration of the model was calculated with the Gronnesby and Borgan test. Simple imputations with multivariate regressions were used for all variables with <5% missingness (except brain natriuretic peptide [BNP] and N-terminal probrain natriuretic peptide [NT-proBNP], which did not meet this criterion).10–13 A value of P<.05 was considered statistically significant. The analysis was performed with SPSS 19 and Stata 12 software.


We included 2254 patients, of which 70% were men. The mean age was 66 (13) years. Some 43% were overweight, 35% were obese, according to their BMI, and 60% had central obesity with a mean WC of 103 (13) cm in men and 101 (15) cm in women. However, we also identified 15 patients (0.7%) with a low BMI (<18.5) who were not analyzed separately as they were too few in number. Table 1 compares baseline clinical characteristics according to BMI and WC. In the group of obese patients, we found a higher percentage of women and a greater incidence of a hypertensive or hypertrophic etiology, diabetes mellitus, dyslipidemia, and high blood pressure. In the normal weight group, we found more anemia, worse New York Heart Association functional class, more depressed left ventricular ejection fraction, more hyponatremia and higher BNP values. A higher WC was significantly associated with the same parameters as obesity and overweight. In this cohort, BMI correlated significantly with WC, with Pearson's r=0.77 (95% confidence interval [95%CI], 0.75-0.78; P<.001).

Table 1.

Baseline Characteristics of Patients According to Body Mass Index and Central Obesity

Variables  Total (n=2254)  BMIP  Waist circumferenceP 
    Normal weight (21.4%)  Overweight (43.3%)  Obese (35.2%)    Normal (39.8%)  Central obesity (60.2%)   
Men, %  70  69  75  64  <.001  86  59  <.001 
Age, years  66.3±12.8  66.4±14.1  66.9±12.4  65.6±12.4  .10  64.8±13.3  67.3±12.3  <.001 
Etiology          <.001      <.001 
Ischemic, %  47  43  50  44  <.01  49  45  .11 
Hypertensive/hypertrophic, %  15  13  21  <.001  19  <.001 
Dilated, %  27  30  27  26  .37  30  25  .01 
Valvular, %  12  <.001  .11 
Other, %  .04  .21 
Clinical history of smoking, %  58  58  62  55  .02  68  52  <.001 
Alcoholism, %  24  20  25  26  .06  26  23  .06 
Diabetes mellitus, %  42  32  41  49  <.001  34  47  <.001 
Dyslipidemia, %  53  41  54  58  <.001  49  55  .01 
HBP, %  68  55  66  78  <.001  58  75  <.001 
Previous AMI, %  38  36  41  36  .04  40  37  .11 
Anemia, %  39  47  41  32  <.001  43  37  <.01 
BMI, kg/m2  29±5  —  —  —  —  25±3  31±5  <.001 
WC, cm  102±14  89±9  100±10  113±12  <.001  —  —  — 
Central obesity, %  60  19  55  92  <.001  —  —  — 
NYHA functional class III-IV, %  57  61  54  58  .02  56  58  .25 
LVEF≥45%  22  16  18  30  <.001  13  28  <.001 
GFR (mL/min/1.73 m2), %  68±26  67±28  67±24  69±27  .08  70±26  67±26  <.01 
Hyponatremia <135 mmol/L, %  11  15  11  <.01  14  <.001 
BNP, pmol/La  137±173  192±223  129±165  101±108  <.01  149±184  127±162  .26 
NT-proBNP, pmol/Lb  401±600  619±852  404±579  281±395  <.001  462±664  363±553  <.01 
Loop-acting diuretics, %  85  86  84  84  .49  85  85  .99 
ACE or ARB inhibitors, %  86  82  86  87  .01  85  86  .39 
Beta-blockers, %  80  77  80  82  .08  80  80  .89 
Antialdosterone drugs, %  56  60  58  50  <.001  61  52  <.001 

ACE inhibitors, angiotensin converting enzyme inhibitors; AMI, acute myocardial infarction; ARB, angiotensin II receptor antagonists; BMI, body mass index; BNP, brain natriuretic peptide; GFR, glomerular filtration rate (MDRD-4 method); HBP, high blood pressure; LVEF, left ventricular ejection fraction; NT–proBNP, N-terminal pro-brain natriuretic peptide; NYHA, New York Heart Association; WC, waist circumference.


Data available for 321 patients.


Data available for 1474 patients.

Central obesity, WC ≥88cm in women and ≥102cm in men.

Categorical variables are presented as percentages and continuous variables as mean±SD.


Patients were followed-up for a maximum 48 months (median, 21 months).

During follow-up, 475 deaths occurred, of which 341 (72%) were from cardiac causes. Total and cardiac mortality at 4 years were 21% and 15%, respectively. Total mortality was lower in patients with a higher BMI: 21.3% in the overweight and 16.4% in the obese groups compared with 28.4% in patients with normal weight (P<.001). The same trend was found for WC: 18.9% in the central obesity group vs 24.3% in patients with normal WC (P<.01). We found a similar trend for cardiac death; mortality was lower in patients with higher BMI: 15.4% in the overweight and 12.3% in the obese groups vs 19.3% in patients with normal weight (P<.01). Concerning WC, we also found lower mortality in obese patients: 13.9% in the central obesity group vs 17.1% in the normal WC group (P=.04).

Multivariate Analysis

Predictors of total mortality were identified using multivariate Cox proportional hazard modeling adjusted for confounding variables (Table 2), in which both higher BMI and WC were identified as factors associated with lower mortality (respectively, HR=0.84; 95%CI, 0.76-0.93; P<.001; HR=0.97; 95%CI, 0.95-0.99; P=.01] with interaction between both (HR=1.001; 95%CI, 1.001-1.002; P<.01). In this interaction, a higher WC attenuated the protective effect of a higher BMI. More detailed analysis of interaction found that in patients with a BMI≥35, a higher WC was associated with worse survival; in fact, when WC was >120cm, we found that higher BMI ceased to have any significant protective effect. Other factors associated with greater total mortality were ischemic and valvular etiology, age, anemia and diabetes mellitus. All models were adjusted for relevant clinical variables such as sex, New York Heart Association functional class, left ventricular ejection fraction, hyponatremia, and glomerular filtration rate, but we found no significant changes in the HR of BMI and WC (change <3%)14; therefore, we opted for the reduced model. The multivariate model obtained a Harrell's C-index of 0.8. The Gronnesby and Borgan test of validity of adjustment showed good calibration of the model (P=.26).

Table 2.

Cox Proportional Hazard Modelling

  HR (95%CI)  P 
All-cause death
Man  1.09 (0.88-1.35)  .42 
Age, years  1.03 (1.02-1.04)  <.001 
Ischemic etiology vs reference (hypertensive/hypertrophic)  1.42 (1.05-1.92)  .02 
Dilated etiology vs reference (hypertensive/hypertrophic)  1.20 (0.85-1.70)  .30 
Valvular etiology vs reference (hypertensive/hypertrophic)  2.69 (1.86-3.89)  <.001 
Other etiology vs reference (hypertensive/hypertrophic)  1.85 (1.13-3.03)  .01 
Diabetes mellitus  1.33 (1.10-1.61)  <.01 
Anemia  1.80 (1.49-2.18)  <.001 
BMI, kg/m2  0.84 (0.76-0.93)  <.001 
WC, cm  0.97 (0.95-0.99)  .01 
BMI*WC (interaction)  1.001 (1.001-1.002)  <.01 
Cardiac death
Man  1.03 (0.80-1.32)  .82 
Age, years  1.03 (1.01-1.04)  <.001 
Ischemic etiology vs reference (hypertensive/hypertrophic)  1.19 (0.77-1.85)  .44 
Dilated etiology vs reference (hypertensive/hypertrophic)  1.29 (0.84-1.97)  .25 
Valvular etiology vs reference (hypertensive/hypertrophic)  3.24 (2.10-5.02)  <.001 
Other etiology vs reference (hypertensive/hypertrophic)  2.20 (1.24-3.91)  <.01 
Diabetes mellitus  1.39 (1.11-1.74)  <.01 
Previous AMI  1.43 (1.04-1.97)  .03 
Anemia  1.85 (1.48-2.31)  <.001 
BMI, kg/m2  0.84 (0.75-0.93)  <.001 
WC, cm  0.97 (0.94-0.99)  .01 
BMI*WC (interaction)  1.001 (1.001-1.002)  <.01 

95%CI, 95% confidence interval; AMI, acute myocardial infarction; BMI, body mass index; HR, hazard ratio; WC, waist circumference.

Similarly, for cardiac mortality (Table 2), we also found that both BMI and WC were protective factors (HR=0.84; 95%CI 0.75-0.93; P<.001; and HR=0.97; 95%CI, 0.94-0.99; P=.01), with interaction between them (HR=1.001; 95%CI, 1.001-1.002; P<.01). In their interaction, we again found that a higher WC attenuated the size of the protective effect of BMI. Other associated risk factors were valvular etiology, age, a history of acute myocardial infarction, anemia, and diabetes mellitus. Similarly, all models were adjusted for the variable sex. The final model was adjusted for clinically relevant variables but we found no significant changes in the HR of BMI and WC (change <5%)14 and opted for the reduced model, as in the case of total mortality. The multivariate model obtained a Harrell's C-index of 0.69. The Gronnesby and Borgan test of validity of adjustment showed good calibration of the model (P=.36).

DISCUSSIONMost Relevant Findings

The results of this study confirm the “obesity paradox”15 in patients hospitalized for HF in the REDINSCOR registry for both BMI and WC. Hence, patients with greater BMI and WC have lower total and cardiac mortality. However, in obese patients with a BMI close to 35, the protective effect of central obesity disappears. These results support the recommendation to measure WC as well as calculating BMI to best determine the risk of total and cardiac mortality in HF.

Obesity Paradox

In recent years, several studies have shown an association between a higher BMI and lower mortality in patients with chronic disease such as chronic kidney failure, rheumatoid arthritis, cancer and, especially, coronary heart disease.16–21 A meta-analysis22 including 40 studies with a total 250 152 patients with ischemic heart disease demonstrated that BMI as an indicator of overweight and obesity was associated with a 16% and 12% lower risk of mortality, respectively. Although several studies point to the obesity paradox,23 much controversy remains about the prognostic value of overweight and obesity and few studies have analyzed the role of central obesity.24 Zamora et al.18 studied 501 patients with HF and 30% median ejection fraction and identified a higher BMI as an independent predictor of lower total mortality at 2 years. Nevertheless, in a subsequent study, the beneficial effect of higher weight was only demonstrated in patients without ischemic heart disease.25 The DIAMOND-CHF registry,26 including 4700 patients with HF and in New York Heart Association functional class III-IV, found improved prognosis associated with greater BMI only in patients with better ventricular function, whereas prognosis worsened in patients with systolic dysfunction. In Spain, a recent study27 using Minimum Basic Data Set data on patients hospitalized for HF found that a diagnosis of obesity reduced mortality and readmissions. Our results confirm earlier findings reported by Zapatero et al.27 and, moreover, confirm the role of WC as a significant independent predictor of lower mortality, but with an attenuating effect in inverse relation between BMI and mortality. Notably, in contrast to Zapatero et al.,27 we included patients prospectively, with direct data collection and >4 years’ follow-up.

Several studies have analyzed possible causal mechanisms underlying the obesity paradox but it seems more than likely that multiple factors are involved. Hence, in obese individuals with HF, symptoms can appear earlier, and therefore diagnosis and treatment occur at earlier stages of the disease. The paradox could also be explained by the greater metabolic reserve in obese individuals, making them more resistant to the increase in catabolism found in of patients with HF. Similarly, obese patients have higher tumor necrosis factor-α (TNFα) receptor values than patients with HF, which could attenuate the negative impact of high TNFα concentrations. Obese patients also have an increase in plasma lipoproteins, which could counter high lipopolysaccharide values, which are a powerful stimulus to the release of inflammatory cytokines.28–33 Finally, cardiac cachexia has been associated with higher mortality, and therefore its absence would improve prognosis, and obesity could be a marker of better prognosis.

Prognostic Value of Waist Circumference Measurement

Currently BMI (weight in kilos divided by height in meters squared) is generally used as a marker of general adiposity; however, several authors have questioned its suitability since BMI does not distinguish between adipose mass and muscle mass, which could lead to incorrect assumptions about the association between obesity and mortality in HF patients. Therefore, it is becoming increasingly clear that measuring total body fat and using markers of central fat such as WC could be better than using BMI alone.15,34 Hence, we measured both BMI and WC in patients with chronic HF.

A higher WC is the most specific marker of central obesity. Together with diabetes mellitus and high blood pressure, it constitutes metabolic syndrome, which is associated with greater cardiovascular risk. The prognostic value of a higher WC in HF has been studied little. In 344 patients with HF and systolic dysfunction, Clark et al.35 analyzed the prognostic value of BMI and WC and found lower total mortality in the group of patients with higher values of both parameters. The beneficial effect was similar in both sexes. However, these studies examined the effect of higher BMI and WC in patients with depressed ejection fraction and advanced HF. Our study included patients diagnosed with HF, without excluding either patients with preserved ejection fraction or others on the basis of HF etiology, thus providing information about the wider population with HF. In fact, in population-wide registries, around 50% of patients requiring hospitalization for HF have preserved ejection fraction. Our study confirmed that a higher BMI and WC were associated with better prognosis. Hence, the relationship between BMI and mortality tended to show a U-shaped curve, which is a type of relationship that usually also occurs in acute and chronic ischemic heart disease.36 For WC, we found a stronger relationship with mortality in J, which demonstrates the added value of measuring WC. Thus, with BMI values ≥35, a higher WC becomes a risk factor, whereas when WC is around 120cm, BMI loses its protective effect.

Total mortality in our study was 21% at 4 years, similar to that of other epidemiologic studies or registries of patients with HF, in which total mortality ranges between 20% and 25%.37,38 Unlike previous studies, in our study the beneficial effect of higher BMI and WC was observed in both total and cardiac mortality. However, as in previous studies, our obese patients were younger, more frequently women, with diabetes, high blood pressure, dyslipidemia and anemia, a lower incidence of smoking, and a higher incidence of ≥45% ejection fraction; the main etiology was hypertension, which was associated with low BNP values. Therefore, in principle, our patients had clinical characteristics associated with greater cardiovascular risk; however, a higher percentage of patients with preserved ejection fraction could be important as it contributes to better prognosis. Similarly, we found significantly lower concentrations of natriuretic peptides in patients with both higher BMI and WC. The reduction in BNP concentrations with increasing weight has been described elsewhere and may be associated with greater sodium and fluid retention, which can increase dyspnea and, therefore, be associated with earlier manifestations of disease even in patients with less severe HF.28,39

Limitations and Strengths of the Study

The study was conducted in a national registry database of patients with HF, which could be considered a limitation. However, this registry was expressly designed to gather data on HF-related factors and exhaustive fulfillment of quality standards and validation of all data introduced by the participating centers was guaranteed. Moreover, data collection was prospective, which considerably improves data quality. A long follow-up period was analyzed, ensuring exhaustive analysis of total and cardiac mortality.


This study confirms low mortality in patients with chronic HF with greater BMI and WC, corroborating the validity of the obesity paradox in the patients studied. In view of the results, WC should be measured together with BMI to better predict the prognosis of chronic HF.


The present study has been financed through a grant from the Spanish Ministry of Science and Innovation, (Redes de Investigación del Instituto de Salud Carlos III, REDINSCOR, RD06/0003) and by the European Regional Development Fund (ERDF).


None declared.

WHO. Overweight and obesity [Internet] [accessed May 2012]. Geneva: World Health Organization. Available at:
Sociedad Española para el Estudio de la Obesidad (SEEDO).
Consenso SEEDO 2007 para la evaluación del sobrepeso y la obesidad y establecimiento de criterios de intervención terapéutica.
Rev Esp Obes, 3 (2007), pp. 135-137
J.P. Després, S. Moorjani, P.J. Lupien, A. Tremblay, A. Nadeau, C. Bouchard.
Regional distribution of body fat, plasma lipoproteins, and cardiovascular disease.
Arteriosclerosis, 10 (1990), pp. 497-511
G. Hu, P. Jousilahti, R. Antikainen, P.T. Katzmarzyk, J. Tuomilehto.
Joint effects of physical activity, body mass index, waist circumference, and waist-to-hip ratio on the risk of heart failure.
Circulation, 121 (2010), pp. 237-244
C.J. Lavie, R.V. Milani, H.O. Ventura.
Obesity and cardiovascular disease: risk factor, paradox, and impact of weight loss.
J Am Coll Cardiol, 53 (2009), pp. 1925-1932
A. Oreopoulos, J.A. Ezekowitz, F.A. McAlister, K. Kalantar-Zadeh, G.C. Fonarow, C.M. Norris, et al.
Association between direct measures of body composition and prognostic factors in chronic heart failure.
Mayo Clin Proc, 85 (2010), pp. 609-617
G. Testa, F. Cacciatore, G. Galizia, D. Della-Morte, F. Mazzella, A. Langellotto, et al.
Waist circumference but not body mass index predicts long-term mortality in elderly subjects with chronic heart failure.
J Am Geriatr Soc, 58 (2010), pp. 1433-1440
K. Dickstein, A. Cohen-Solal, G. Filippatos, J.J. McMurray, P. Ponikowski, P.A. Poole-Wilson, ESC Committee for Practice Guidelines (CPG). ESC guidelines for the diagnosis and treatment of acute and chronic heart failure 2008: the Task Force for the diagnosis and treatment of acute and chronic heart failure 2008 of the European Society of Cardiology, et al.
Developed in collaboration with the Heart Failure Association of the ESC (HFA) and endorsed by the European Society of Intensive Care Medicine (ESICM).
Eur J Heart Fail, 10 (2008), pp. 933-989
Red de investigación clínica y básica en insuficiencia cardiaca (REDINSCOR) [website] [accessed May 2012]. Redes temáticas de investigación cooperativa del Instituto de Salud Carlos III. Available at:
J.S. Haukoos, C.D. Newgard.
Advanced statistics: missing data in clinical research — part 1: an introduction and conceptual framework.
Acad Emerg Med, 14 (2007), pp. 662-668
E. Núñez, E.W. Steyerberg, J. Núñez.
Estrategias para la elaboración de modelos estadísticos de regresión.
Rev Esp Cardiol, 64 (2011), pp. 501-507
R.J.A. Little, D.B. Rubin.
Statistical analysis with missing data.
Wiley, (1987),
J.M. Doménech, J.B. Navarro.
Regresión múltiple con predictores categóricos y cuantitativos.
6th ed., Signo, (2011),
J.M. Doménech, J.B. Navarro.
Análisis de la supervivencia y modelos de riesgos proporcionales de Cox.
6th ed., Signo, (2011), pp. 245
P. Srikanthan, T.B. Horwich.
La paradoja de la obesidad, es hora de adoptar una perspectiva nueva sobre un paradigma antiguo.
Rev Esp Cardiol, 65 (2012), pp. 403-404
P. Gastelurrutia, D. Pascual-Figal, R. Vázquez, I. Cygankiewicz, L.G. Shamagian, T. Puig, et al.
Obesity paradox and risk of sudden death in heart failure results from the MUerte Subita en Insuficiencia cardiaca (MUSIC) study.
Am Heart J, 161 (2011), pp. 158-164
J.C. Trullàs, F. Formiga, M. Montero, A. Conde, J. Casado, F.J. Carrasco, Grupo RICA, et al.
[Paradox of obesity in heart failure: results from the Spanish RICA Registry].
Med Clin (Barc), 137 (2011), pp. 671-677
E. Zamora, J. Lupón, A. Urrutia, B. González, D. Mas, T. Pascual, et al.
¿El índice de masa corporal influye en la mortalidad de los pacientes con insuficiencia cardiaca?.
Rev Esp Cardiol, 60 (2007), pp. 1127-1134
S. Kenchaiah, J.C. Evans, D. Levy, P.W. Wilson, E.J. Benjamin, M.G. Larson, et al.
Obesity and the risk of heart failure.
N Engl J Med, 347 (2002), pp. 305-313
T.B. Horwich, G.C. Fonarow, M.A. Hamilton, W.R. MacLellan, M.A. Woo, J.H. Tillisch.
The relationship between obesity and mortality in patients with heart failure.
J Am Coll Cardiol, 38 (2001), pp. 789-795
C.J. Lavie, A.F. Osman, R.V. Milani, M.R. Mehra.
Body composition and prognosis in chronic systolic heart failure: the obesity paradox.
Am J Cardiol, 91 (2003), pp. 891-894
A. Romero-Corral, V.M. Montori, V.K. Somers, J. Korinek, R.J. Thomas, T.G. Allison, et al.
Association of bodyweight with total mortality and with cardiovascular events in coronary artery disease: a systematic review of cohort studies.
C.J. Lavie, R.V. Milani, H.O. Ventura.
Obesity and the «obesity paradox» in cardiovascular diseases.
Clin Pharmacol Ther, 90 (2011), pp. 23-25
A.L. Clark, G.C. Fonarow, T.B. Horwich.
Waist circumference, body mass index, and survival in systolic heart failure: the obesity paradox revisited.
J Card Fail, 17 (2011), pp. 374-380
E. Zamora, J. Lupón, M. De Antonio, A. Urrutia, R. Coll, C. Díez, et al.
The obesity paradox in heart failure: Is etiology a key factor?.
Int J Cardiol, 166 (2013), pp. 601-605
F. Gustafsson, C.B. Kragelund, C. Torp-Pedersen, M. Seibaek, H. Burchardt, D. Akkan, et al.
Effect of obesity and being overweight on long-term mortality in congestive heart failure: influence of left ventricular systolic function.
Eur Heart J, 26 (2005), pp. 58-64
A. Zapatero, R. Barba, N. González, J.E. Losa, S. Plaza, J. Canora, et al.
Influencia de la obesidad y la desnutrición en la insuficiencia cardiaca aguda.
Rev Esp Cardiol, 65 (2012), pp. 421-426
M.R. Mehra, P.A. Uber, M.H. Park, R.L. Scott, H.O. Ventura, B.C. Harris, et al.
Obesity and suppressed B-type natriuretic peptide levels in heart failure.
J Am Coll Cardiol, 43 (2004), pp. 1590-1595
C.J. Lavie, M.R. Mehra, R.V. Milani.
Obesity and heart failure prognosis: paradox or reverse epidemiology?.
Eur Heart J, 26 (2005), pp. 5-7
K. Kalantar-Zadeh, G. Block, T. Horwich, G.C. Fonarow.
Reverse epidemiology of conventional cardiovascular risk factors in patients with chronic heart failure.
J Am Coll Cardiol, 43 (2004), pp. 1439-1444
S.D. Anker, A. Negassa, A.J. Coats, R. Afzal, P.A. Poole-Wilson, J.N. Cohn, et al.
Prognostic importance of weight loss in chronic heart failure and the effect of treatment with angiotensin-converting-enzyme inhibitors: an observational study.
Lancet, 361 (2003), pp. 1077-1083
V. Mohamed-Ali, S. Goodrick, K. Bulmer, J.M. Holly, J.S. Yudkin, S.W. Coppack.
Production of soluble tumor necrosis factor receptors by human subcutaneous adipose tissue in vivo.
Am J Physiol, 277 (1999), pp. E971-E975
M. Rauchhaus, A.J. Coats, S.D. Anker.
The endotoxin-lipoprotein hypothesis.
F. López-Jiménez, M. Cortés-Bergoderi.
Obesidad y corazón.
Rev Esp Cardiol, 64 (2011), pp. 140-149
A.L. Clark, J. Chyu, T.B. Horwich.
The obesity paradox in men versus women with systolic heart failure.
Am J Cardiol, 110 (2012), pp. 77-82
O. Angerås, P. Albertsson, K. Karason, T. Råmunddal, G. Matejka, S. James, et al.
Evidence for obesity paradox in patients with acute coronary syndromes: a report from the Swedish Coronary Angiography and Angioplasty Registry.
Eur Heart J, 34 (2013), pp. 345-353
V.L. Roger, S.A. Weston, M.M. Redfield, J.P. Hellermann-Homan, J. Killian, B.P. Yawn, et al.
Trends in heart failure incidence and survival in a community-based population.
JAMA, 292 (2004), pp. 344-350
T.E. Owan, D.O. Hodge, R.M. Herges, S.J. Jacobsen, V.L. Roger, M.M. Redfield.
Trends in prevalence and outcome of heart failure with preserved ejection fraction.
N Engl J Med, 355 (2006), pp. 251-259
T.B. Horwich, M.A. Hamilton, G.C. Fonarow.
B-type natriuretic peptide levels in obese patients with advanced heart failure.
J Am Coll Cardiol, 47 (2006), pp. 85-90

The list of researchers collaborating in the REDINSCOR registry can be consulted in the supplementary material to this article.

Copyright © 2013. Sociedad Española de Cardiología
Revista Española de Cardiología (English Edition)

Subscribe to our newsletter

View newsletter history
Article options
Supplemental materials
es en

¿Es usted profesional sanitario apto para prescribir o dispensar medicamentos?

Are you a health professional able to prescribe or dispense drugs?