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Vol. 6. Núm. G.
Tratamiento de las hiperlipemias en pacientes con riesgo cardiovascular elevado
Páginas 36G-45G (Septiembre 2006)
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Vol. 6. Núm. G.
Tratamiento de las hiperlipemias en pacientes con riesgo cardiovascular elevado
Páginas 36G-45G (Septiembre 2006)
Tratamiento de las hiperlipemias en pacientes con riesgo cardiovascular elevado
Acceso a texto completo
Prevención y tratamiento del síndrome coronario agudo
Prevention and Treatment of Acute Coronary Syndrome
Visitas
...
Antonio J. Domínguez Franco, Margarita Pérez Caravante, Manuel F. Jiménez Navarro, Eduardo de Teresa Galván??
Autor para correspondencia
edeteresa@secardiologia.es

Correspondencia: Dr. E. de Teresa. Servicio de Cardiología. Hospital Clínico Universitario Virgen de la Victoria. Campus de Teatinos, s/n. 29010 Málaga. España.
Servicio de Cardiología. Hospital Clínico Universitario Virgen de la Victoria. Málaga. España
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Los síndromes coronarios agudos (SCA) son la manifestación clínica final de un proceso inflamatorio crónico de la pared vascular puesto en marcha por diferentes agentes que causan daño en el endotelio. La rotura o la erosión de la placa aterosclerótica vulnerable provocan la trombosis y la aparición de los SCA. La respuesta inflamatoria local y sistémica desempeña un papel fundamental en la vulnerabilidad y la rotura de la placa. En el presente artículo revisaremos la fisiopatología, las técnicas disponibles para la detección de la placa vulnerable, el papel de las estatinas en el SCA (ensayos clínicos publicados) y las implicaciones terapéuticas para la prevención de las complicaciones trombóticas de la aterosclerosis.

Palabras clave:
Síndrome coronario agudo
Inflamación
Placa vulnerable
Aterosclerosis
Trombosis
Estatinas
Prevención

Acute coronary syndrome is the ultimate clinical manifestation of the chronic inflammation of the vascular wall that results from various processes which damage the endothelium. Rupture of atherosclerotic plaque causes thrombosis and leads to acute coronary syndromes. Both local and systemic inflammatory responses have important influences on plaque vulnerability and rupture. In the present article, we review disease pathophysiology, the techniques available for detecting vulnerable plaque, the role of statins in acute coronary syndromes (based on published clinical trials), and the therapeutic implications of preventing the thrombotic complications of atherosclerosis.

Key words:
Acute coronary syndrome
Inflammation
Vulnerable plaque
Atherosclerosis
Thrombosis
Statins
Prevention
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