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Vol. 60. Issue 7.
Pages 784 (July 2007)
Vol. 60. Issue 7.
Pages 784 (July 2007)
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Hypertrophic Cardiomyopathy and the Implantable Cardioverter¿Defibrillator
Miocardiopatía hipertrófica y desfibrilador automático implantable
Ana J Manovel-Sáncheza, Alonso Pedrote-Martíneza, Eduardo Arana-Ruedaa, Francisco Errazquin-Sáenz de Tejadaa
a Servicio de Cardiología, Hospital Universitario Virgen del Rocío, Sevilla, Spain
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To the Editor:

We have read the article by Marín et al1 with interest and would like to describe the results of a similar study conducted at our hospital.

We studied 20 patients with hypertrophic cardiomyopathy (HCM) and implantable cardioverter defibrillator (ICD) between January 1993 and April 2005. The ICD was implanted for both secondary prevention (SP) and primary prevention (PP), with the latter considered to be the presence of 1 or more risk factors recognized as predictors of sudden death.2 The ICD was indicated for SP in 14 patients (70%), (7 with sudden death and 7 with sustained ventricular tachycardia), and PP in 6 (30%); among the PP group, 33% had a single risk factor. During a median follow-up of 6.5 years (PP 3 years vs SP 7 years; P=.016), 2 patients died, 1 in each prevention group (overall survival, 94% [5]). The percentage of patients free of appropriate shocks was 55% (12%) (PP 66% [19] vs SP 52% [14]; P=.87), with most patients receiving initial therapy in the first year of follow-up. Four (44%) of the patients with appropriate shocks had only 1 risk factor. There were no significant differences in appropriate shocks among those who had 1 or more risk factors (hazard ratio [HR], 1.25; 95% confidence interval [CI], 0.47-3.33), and no factors were significantly associated with a greater percentage of appropriate shocks. Inappropriate shocks were observed in 40%: 1 (16%) during PP and 7 (50%) during SP (P=.4). The main causes were sinus tachycardia, followed by atrial fibrillation, with 1 case due to oversensing; 50% of these also had appropriate shocks during follow-up.

We would like to make several comments about the use of the ICD to prevent sudden death in HCM and to compare our findings with the recent study published in this journal by Marín et al.1 First, our patients presented a high percentage of appropriate shocks (45%), higher than the values reported up to now and probably attributable to the longer follow-up time. The indication of an ICD for PP in these patients is increasingly accepted in light of recently published studies3-5; however, whether or not the presence of a single risk factor justifies implantation is still controversial and the major difference among the various research groups. Our group reflects a less restrictive indication. A third of our patients received an implant for a single risk factor, versus 4.4% in Marín's study.1 In the latter, the significantly lower percentage of appropriate shocks in the PP group makes the predictive value of a single risk factor alone questionable for justifying implantation of an ICD. Unlike the published series, we found a high percentage of appropriate shocks (33%) in this prevention group, but no differences in the percentage of appropriate therapies between the 2 groups, probably because of the smaller number of patients in PP. The low number of patients is an important limitation and, as mentioned by the authors of the cited article,1 more studies and research on new risk markers are needed to assess the efficacy of the ICD in PP. Multicenter studies such as the study underway6 will make a significant contribution in this regard.

Marín F, Gimeno JR, Payá E, García-Alberola A, Pérez-Álvarez L, Fernández X, et al..
Desfibrilador automático implantable en la miocardiopatía hipertrófica. Experiencia de 3 centros..
Rev Esp Cardiol, 59 (2006), pp. 537-44
Maron BJ, McKenna WJ, Danielson GK, Kappenberg LJ, Kuhn HJ, Seiman CE, et al..
American College of Cardiology/European Society of Cardiology Clinical Expert consensus Document on Hypertrophic cardiomyopathy. A report of the American College of Cardiology Task Force on Clinical Expert Consensus Documents and the European Society of Cardiology Committee for Practice Guidelines Committee to Develop an Expert Consensus Document on Hypertrophic Cardiomyopathy..
J Am Coll Cardiol, 42 (2003), pp. 1687-713
Maron BJ, Shen WK, Link MS, Epstein AE, Almquist AK, Daubert JP, et al..
Efficacy of implantable cardioverter-defibrillators for prevention of sudden death in patients with hypertrophic cardiomyopathy..
N Engl J Med, 342 (2000), pp. 365-73
Begley DA, Mohiddin SA, Tripodi D, Winkler JB, Fananapazir L..
Efficacy of Implantable cardioverter defibrillator therapy for primary and secondary prevention of sudden cardiac death in hypertrophic cardiomyopathy..
Pacing Clin Electrophysiol, 26 (2003), pp. 1887-96
Pedrote A, Morales FJ, García-Riesco L, Errazquin F..
Documented exercise-induced cardiac arrest in a paediatric patient with hypertrophic cardiomyopathy..
Europace, 8 (2006), pp. 430-3
Efficacy of the implantable defibrillator for prevention of sudden death in hypertrophic cardiomyopathy: data from the international registry of 506 high risk patients (abstract). Circulation. 2005;112 Suppl II:531.
Revista Española de Cardiología (English Edition)

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