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Vol. 68. Issue 8.
Pages 647-648 (August 2015)
DOI: 10.1016/j.rec.2015.04.006
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Refining Determination of Cardiac Involvement in Amyloidosis With Three-dimensional Speckle Tracking Echocardiography
Perfeccionamiento de la determinación de la afectación cardiaca en la amiloidosis mediante ecocardiografía speckle tracking (rastreo de marcas) tridimensional
John Gorcsan
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Corresponding author: University of Pittsburgh Medical Center, Heart and Vascular Institution, Scaife Hall, Suite S-564, 200 Lothrop Street, Pittsburgh, Pennsylvania, 15213-2582, United States.
, Antonia Delgado-Montero
The University of Pittsburgh Medical Center, Heart and Vascular Institution, Pittsburgh, Pennsylvania, United States
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Rev Esp Cardiol. 2015;68:657-6410.1016/j.rec.2015.01.009
Jose Angel Urbano-Moral, Dakshin Gangadharamurthy, Raymond L. Comenzo, Natesa G. Pandian, Ayan R. Patel
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Amyloidosis is a severe disease that often has devastating clinical consequences. Determination of cardiac involvement is of great importance. In the article published in Revista Española de Cardiología, Urbano-Moral et al1 investigated 40 patients with light chain amyloidosis to extend the diagnostic utility of echocardiography by applying the exciting new technique of 3-dimensional (3D) speckle tracking echocardiography. Because amyloidosis is uncommon, echocardiography has traditionally played a critically important diagnostic role in identifying features consistent with cardiac amyloidosis.2 These echocardiographic features may frequently alert clinicians to pursue appropriate diagnostic testing, such as biopsy, or suggest cardiac involvement in patients with laboratory evidence of systemic amyloidosis. Importantly, over half of patients affected by this condition show cardiac involvement at diagnosis, which is the most important prognostic factor.

Amyloidosis is an unusual disease of unknown cause with a variable clinical course and limited treatment options. Establishing the diagnosis may be complex, requiring positive amyloid Congo red staining by fat aspirate, bone marrow biopsy, or cardiac biopsy. In addition, immunohistochemical staining or immunofluorescence microscopy may detect evidence of light chain-related amyloid, while serum or urine immunofixation may detect a monoclonal plasma cell proliferative disorder using serum- or bone marrow-free light chain ratio analysis. Systemic amyloidosis often results in deposition of amyloid substance in the heart, which affects myocardial function in unique and interesting ways. Determination of cardiac involvement may vary among different subtypes of amyloid disease, and diagnostic information in addition to echocardiography may be obtained from the standard 12-lead electrocardiogram, serum biomarkers, cardiac magnetic resonance imaging, and nuclear techniques.3 Echocardiographic criteria have been most commonly used for clinical diagnosis, including the simple observation of increased wall thickness that is not left ventricular (LV) hypertrophy. Shortened deceleration time by pulsed Doppler of the mitral inflow velocity was introduced by Klein et al,4 and reduced early diastolic tissue Doppler mitral annular velocity by Garcia et al.5 These Doppler criteria remain an established part of the diagnostic approach to amyloidosis.

Speckle tracking echocardiography, also known as deformation imaging, has had a major impact on the quantification of myocardial mechanics and has established clinical utility.6–8 An exciting observation was made by Phelan et al9 using speckle-tracking longitudinal strain segmental analysis to demonstrate relative apical sparing to differentiate wall thickening from cardiac amyloidosis from other more common causes of LV wall thickening, such as hypertensive heart disease or aortic stenosis. These authors showed that the segmental longitudinal strain ratio of average apical strain/average mid- and basal strain with a value more than 1.0 indicated apical sparing consistent with amyloidosis, with 93% sensitivity and 82% specificity. A recent study by Baccouche et al10 used the same vendor to analyze and compare 2-dimensional (2D) and 3D assessment in 24 participants, 12 with cardiac amyloid and 12 with hypertrophic cardiomyopathy. These authors described similar relative longitudinal and circumferential apical sparing, showing an “inverse pattern” of radial strain with higher values in apical segments, which progressively decreased toward the base. In contrast, healthy controls showed a normal radial strain gradient of basal to apical decreasing radial strain. As expected, hypertrophic cardiomyopathy patients showed significantly lower values than healthy participants. Using cardiac magnetic resonance imaging with late gadolinium enhancement, the authors demonstrated a basal to apical gradient in hypertrophic cardiomyopathy diseases, although it was much more pronounced in cardiac amyloid.10

More recently, Quarta et al11 reported 2D speckle tracking echocardiographic data from a large series of 172 patients with cardiac amyloidosis. These authors included 80 patients with amyloid light-chain amyloidosis, 56 patients with nonmutant transthyretin-related amyloidosis, and 36 patients with transthyretin-related mutant-form amyloidosis. They observed that 100% of patients with cardiac amyloidosis had abnormal radial strain and 93% had abnormal longitudinal strain, reporting that strain performed better than routine pulsed Doppler or tissue Doppler in detecting cardiac involvement.

The present study by Urbano-Moral et al1 builds on these previous studies by adding evaluation of cardiac amyloidosis by the newer technology of 3D speckle tracking echocardiography. Three-dimensional strain techniques continue to develop quickly and have been shown to be useful in accurately measuring cardiac chamber volumes, segmental and global function, and intraventricular dyssynchrony.12 The present report confirms previous observations by 2D speckle tracking of greater involvement of the basal segments than the apical segments. Furthermore, the authors associated the degree of abnormalities in 3D speckle tracking strain with the degree of elevation in the serum biomarker, brain natriuretic peptide, an established marker of disease extent and prognosis in heart failure. They showed that LV longitudinal and circumferential strain were reduced in patients with cardiac involvement (-9 ± 4 vs -16±2; P < .001, and -24 ± 6 vs -29 ± 4; P = .01, respectively), with the most prominent impairment at the basal segments. They introduced the assessment of right ventricular (RV) 3D strain and showed that the reduced RV strain measurements were correlated to changes in LV strain in cardiac amyloidosis; however, they could not apply RV strain to many patients, and RV strain assessment appears to be currently limited in their experience. Most importantly, they used a multivariable analysis to demonstrate that 3D LV longitudinal strain was associated with the presence of cardiac involvement (odds ratio = 1.6; 95% confidence interval, 1.04-2.37; P = .03), independently of the presence of brain natriuretic peptide and troponin I criteria for cardiac amyloidosis.

The limitations of 3D speckle tracking include the need for adequate image quality, with 9% being excluded for 3D LV strain analysis and 41% being excluded for 3D RV strain analysis. In addition, there are marked differences in acquisition rates compared with 2D speckle tracking, with 3D technique having lower volume rates.13 Other limitations include the need for user training to limit interobserver variability in the placement of regions of interest affecting data output and variability reported from different vendors.14,15

In conclusion, the study by Urbano-Moral et al1 extends the diagnostic utility of echocardiography in detecting and quantifying cardiac involvement in amyloidosis. This new information builds on previous clinical information obtained from a low voltage electrocardiogram, shortened mitral inflow deceleration time by pulsed Doppler, and reduced tissue Doppler mitral early diastolic velocity. Speckle tracking strain echocardiography in terms of global longitudinal strain appears to be a highly sensitive indicator of cardiac amyloidosis that may be superior to previous approaches and at least deserves clinical attention. These enhancements in the diagnosis of cardiac amyloidosis are accompanied by exciting recent advances in treatment options, which all result in improvements in patient care.


J. Gorcsan receives research grant support from Toshiba, Medical Inc.

J.A. Urbano-Moral, D. Gangadharamurthy, R.L. Comenzo, N.G. Pandian, A.R. Patel.
Ecocardiografía speckle tracking (rastreo de marcas) tridimensional en la amiloidosis cardiaca de cadenas ligeras: estudio de los parámetros de mecánica miocárdica ventricular izquierda y derecha.
Rev Esp Cardiol., 68 (2015), pp. 657-664
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Copyright © 2015. Sociedad Española de Cardiología
Revista Española de Cardiología (English Edition)

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