Publish in this journal
Journal Information
Vol. 70. Issue 6.
Pages 516 (June 2017)
Letter to the Editor
DOI: 10.1016/j.rec.2016.12.027
Full text access
Relaxin Concentrations in Acute Heart Failure Patients
Concentración de relaxina en pacientes con insuficiencia cardiaca aguda
Visits
...
Dennis R. Stewart
Molecular Medicine Research Institute, Sunnyvale, California, United States
Related content
Rev Esp Cardiol. 2016;69:1230-210.1016/j.rec.2016.09.007
Jorge Martínez Solano, Juan José Santos Mateo, Jesús Sánchez-Más, Juan Sánchez, Mari Carmen Asensio López, Domingo Pascual Figal
Rev Esp Cardiol. 2017;70:516-710.1016/j.rec.2017.02.034
Jesus Sánchez-Más, M. Carmen Asensio-López, Ángela Soriano-Filiu, Domingo Pascual-Figal
This item has received
...
Visits
(Daily data update)
Article information
Full Text
Bibliography
Download PDF
Statistics
Full Text
To the Editor,

I have read the article entitled, “Relaxin Concentrations in Acute Heart Failure Patients: Kinetics and Clinical Determinants”, that appeared in Revista Española de Cardiología.1 This article reports the measurement of serum relaxin in patients with acute heart failure.

I note that the authors used a commercial enzyme-linked immunoassay kit from Immundiagnostik, reporting that this is a validated assay for measuring serum relaxin. However, this assay has not been properly validated for serum relaxin, neither by the authors nor the manufacturer of the assay. No assurance has been given that serum samples dilute in parallel with authentic H2 standards. Specificity for H2 relaxin and cross-reactivity for possible interfering molecules has not been provided by the authors or the manufacturer. The sole exception is that the manufacturer reports that insulin does not interfere but no details are provided on the insulin doses tested. Although it is true that others have reported results using this assay, they also failed to report any assay validation. Because this assay relies on polyclonal antibodies, assay validation needs to be rigorous; however, it is completely absent. Thus, no valid conclusions can be drawn from the data presented in this article. The authors could have used a commercially available assay for serum relaxin that has been validated for clinical studies.2–4

References
[1]
J. Martínez Solano, J.J. Santos Mateo, J. Sánchez-Más, J. Sánchez, M.C. Asensio López, D. Pascual Figal.
Relaxin Concentrations in Acute Heart Failure Patients: Kinetics and Clinical Determinants.
Rev Esp Cardiol., 69 (2016), pp. 1230-1232
[2]
Z. Kobalava, S. Villevalde, Y. Kotovskaya, et al.
Pharmacokinetics of serelaxin in patients with hepatic impairment: A single-dose, open-label, parallel-group study.
Br J Clin Pharmacol., 79 (2014), pp. 937-945
[3]
M. Dahlke, A. Halabi, J. Canadi, C. Tsubouchi, S. Machineni, Y. Pang.
Pharmacokinetics of serelaxin in patients with severe renal impairment or end-stage renal disease requiring hemodialysis: A single-dose, open-label, parallel-group study.
J Clin Pharmacol., 56 (2016), pp. 474-483
[4]
M. Dahlke, D. Ng, M. Yamaguchi, et al.
Safety and tolerability of serelaxin, a recombinant human relaxin-2 in development for the treatment of acute heart failure, in healthy Japanese volunteers and a comparison of pharmacokinetics and pharmacodynamics in healthy Japanese and Caucasian populations.
J Clin Pharmacol., 55 (2015), pp. 415-422
Copyright © 2016. Sociedad Española de Cardiología
Idiomas
Revista Española de Cardiología (English Edition)

Subscribe to our newsletter

Article options
Tools
es en

¿Es usted profesional sanitario apto para prescribir o dispensar medicamentos?

Are you a health professional able to prescribe or dispense drugs?

es en
Política de cookies Cookies policy
Utilizamos cookies propias y de terceros para mejorar nuestros servicios y mostrarle publicidad relacionada con sus preferencias mediante el análisis de sus hábitos de navegación. Si continua navegando, consideramos que acepta su uso. Puede cambiar la configuración u obtener más información aquí. To improve our services and products, we use "cookies" (own or third parties authorized) to show advertising related to client preferences through the analyses of navigation customer behavior. Continuing navigation will be considered as acceptance of this use. You can change the settings or obtain more information by clicking here.