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Vol. 71. Issue 3.
Pages 225-227 (March 2018)
Vol. 71. Issue 3.
Pages 225-227 (March 2018)
Scientific letter
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Selection of the Best of 2017 in Left Atrial Appendage Occlusion: Filling the Gap in Knowledge
Selección de lo mejor del año 2017 en cierre percutáneo de la orejuela izquierda: completando la evidencia científica
Armando Pérez de Pradoa,
Corresponding author

Corresponding author:
, Ana Serradorb, Pilar Jiménez-Quevedoc, Tomás Benito Gonzáleza, Felipe Fernández Vázqueza, Manuel Pand
a Servicio de Cardiología, Hospital Universitario de León, León, Spain
b Servicio de Cardiología, Hospital Clínico Universitario, CIBERCV, Valladolid, Spain
c Servicio de Cardiología, Hospital Clínico San Carlos, Instituto de Investigación Sanitaria San Carlos (IdISSC), Madrid, Spain
d Servicio de Cardiología, Hospital Universitario Reina Sofía, Universidad de Córdoba, Instituto Maimónides de Investigación Biomédica de Córdoba (IMIBIC), Córdoba, Spain
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Table. Recently Published Studies on Percutaneous Closure of the Left Atrial Appendage
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To the Editor,

It has been demonstrated that percutaneous closure of the left atrial appendage (LAA) is an alternative to oral anticoagulation (OAC) with coumarins in patients with nonvalvular atrial fibrillation (AF), especially in those with a contraindication. However, the latest European guidelines on AF1 have not changed the previous grade of recommendation for LAA occlusion and they have retained a class IIb indication and level of evidence B for patients with a long-term contraindication for OAC due to untreatable bleeding problems. The justification for this decision lies in the high real-world complication rates, which are based on the analysis of insurance company databases, systematic reviews, and the lack of current data on LAA occluders compared with the new direct OACs for embolic prevention (sections 9.3.1 and 15.6 of the guidelines). In addition, the guidelines recognize other gaps in the evidence, such as the role of LAA occlusion in managing patients who have already experienced bleeding or stroke (section 15.7) or after intracranial hemorrhage (section 9.4.3).

Several articles2–4 have been recently published that address these aspects and offer guidance on clinical decision making. Table 1 shows their main characteristics and results. Although these studies are observational single cohort studies or propensity score-matched control group studies, they provide valuable information in fields as complex as embolic prevention after bleeding (especially after intracranial hemorrhage) or very high risk of bleeding. In general, they demonstrate the efficacy and safety of LAA occlusion compared with the standard treatment of these patients (many of whom are without OAC due to their bleeding risk). Even the 2 matched control group studies (Nielsen-Kudsk et al.2 and Gloeker et al. [NCT02787525]) demonstrate reductions in overall mortality. Another common finding is the wide variability in pharmacological treatment after LAA occlusion, reflecting the heterogeneity of patients with bleeding or at high risk of bleeding.


Recently Published Studies on Percutaneous Closure of the Left Atrial Appendage

  Nielsen-Kudsk et al.2  Cruz-González et al.3  Korsholm et al.4  Gloekler et al. (NCT02787525
Type of study  Propensity score-matched  Observational  Observational  Propensity score-matched 
Indication for LAA occlusion  Intracranial hemorrhage  Intracranial hemorrhage  Previous bleeding or high bleeding risk  Not defined 
Number of patients  151 + 151 pairs with SMT aspirin, 44%; without treatment, 31%  47  110  500 + 500 pairs treated with OAC(D) 
CHA2D2S-VASc  3.9  4.4  4.3 
HAS-BLED  4.2  4.1 
Treatment after LAA occlusion  Aspirin only, 62%  Dual antiplatelet, 81%  Aspirin only, 85% 
Follow-up, patient-y  150  108  265  2645 
Mortality per 100 patient-y  1.7 vs 15.6; HR = 0.11*  7.5  8.3 vs 11.6; HR = 0.72* 
Ischemic stroke per 100 patient-y  1.7 vs 8.1; HR = 0.21  2.3; RRR, 61%  2.0 vs 3.2; HR = 0.62 
ICH per 100 patient-y  0.8 vs 9.5; HR = 0.10*  1.4  0.1 vs 0.5; HR = 0.20 
Major bleeding per 100 patient-y  3.5 vs 9.5; HR = 0.28*  3.8; RRR, 57%  3.6 vs 4.6; HR = 0.80 
Net benefit per 100 patient-y  5.3 vs 36.7; HR = 0.16*  8.1 vs 10.9; HR = 0.76* 

ICH, intracranial hemorrhage; HR, hazard ratio; LAA, left atrial appendage, OAC(D), direct oral anticoagulants; RRR, relative risk reduction (relative to the predicted value according to the scales); SMT, standard medical treatment.

*P <.05.

In all these studies, a common feature is the absence of procedure- or device-related deaths. Evidence in support of reductions in the incidence of complications has already been shown in device-use registries, such as EWOLUTION5, which reported implantation success rates of more than 98% and major complications related to the procedure or device of less than 3%. Even in groups with less experience, there are very acceptable complication rates, which are probably due to widespread dissemination of knowledge of the technique and shorter learning periods. It seems then that one of the justifications for retaining the IIb indication in the guidelines is weakening. The program developed by the Spanish Health Ministry to monitor the results of this technique should help clarify doubts on this issue (Figure 1).


Left atrial appendage: angiography (A, LAA 30°- caudal 20°) and transesophageal echocardiogram (B, 45° view; C, 135° view). Placement of Watchman device (D), which occludes the appendage (E, angiography; F, 3D transesophageal echocardiogram).


In the very near future, more information will be provided by studies comparing percutaneous LAA occlusion with the new direct OACs. These studies include: Evaluation of WATCHMAN Left Atrial Appendage Occlusion Device in Patients With Atrial Fibrillation Versus Rivaroxaban (NCT02549963); PRAGUE-17: Left Atrial Appendage Closure vs. Novel Anticoagulation Agents in Atrial Fibrillation (NCT02426944); A Pilot Study of Edoxaban in Patients With Non-Valvular Atrial Fibrillation and Left Atrial Appendage Closure (NCT03088072); Safety and Efficacy of Left Atrial Appendage Closure Versus Antithrombotic Therapy in Patients With Atrial Fibrillation Undergoing Drug-Eluting Stent Implantation Due to Complex Coronary Artery Disease (NCT02606552); and Prevention of Stroke by Left Atrial Appendage Closure in Atrial Fibrillation Patients After Intracerebral Hemorrhage (NCT02830152).

These studies will also increase knowledge in another area in which LAA occlusion has been shown to be superior to OAC therapy: that is, cost-effectiveness analysis. Previous studies6 have shown that LAA occlusion is superior (ie, the most effective and least costly) to direct OAC therapy at 5 years and warfarin therapy at 10 years.

In conclusion, percutaneous LAA occlusion is a well-established therapy for highly complex patients (previous bleeding, intracranial hemorrhage) in whom it is difficult to apply OAC therapy. We look forward to the results of comparisons between this technique and the new direct OACs. These results should fill in knowledge gaps and encourage the grade of recommendation of this therapy to be upgraded in the next update of the AF guidelines.


A Pérez de Prado is a proctor in LAA occlusion procedures for Boston Scientific. M Pan has been a scientific speaker for Abbott Vascular.


P. Kirchhof, S. Benussi, D. Kotecha, 2016 ESC Guidelines for the management of atrial fibrillation developed in collaboration with EACTS, et al.
Eur Heart J., 37 (2016), pp. 2893-2962
J.E. Nielsen-Kudsk, S.P. Johnsen, P. Wester, et al.
Left atrial appendage occlusion versus standard medical care in patients with atrial fibrillation and intracerebral haemorrhage: a propensity score-matched follow-up study.
EuroIntervention., 13 (2017), pp. 371-378
I. Cruz-González, J.C. Rama-Merchan, S. Martínez-Peralta, L. López-Mesonero, J. Rodríguez-Collado, P.L. Sánchez.
Eficacia y seguridad del cierre percutáneo de orejuela izquierda en pacientes con hemorragia intracraneal.
Rev Esp Cardiol., 70 (2017), pp. 58-60
K. Korsholm, K.M. Nielsen, J.M. Jensen, H.K. Jensen, G. Andersen, J.E. Nielsen-Kudsk.
Transcatheter left atrial appendage occlusion in patients with atrial fibrillation and a high bleeding risk using aspirin alone for post-implant antithrombotic therapy.
EuroIntervention., 12 (2017), pp. 2075-2082
L.V. Boersma, B. Schmidt, T.R. Betts, et al.
Implant success and safety of left atrial appendage closure with the WATCHMAN device: peri-procedural outcomes from the EWOLUTION registry.
Eur Heart J., 37 (2016), pp. 2465-2474
V.Y. Reddy, R.L. Akehurst, S.O. Armstrong, S.L. Amorosi, S.M. Beard.
Holmes DR Jr. Time to cost-effectiveness following stroke reduction strategies in AF: Warfarin versus NOACs versus LAA closure.
J Am Coll Cardiol, 66 (2015), pp. 2728-2739
Copyright © 2017. Sociedad Española de Cardiología
Revista Española de Cardiología (English Edition)

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