The Kinetics of Metalloproteinase-9: The Significance of the Light-Dark Cycle in Metalloproteinase-9 in Acute Coronary Syndrome

doi:10.1016/S1885-5857(08)60123-1

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Vol. 61. Num. 3.

Pages 327 (March 2008)

The Kinetics of Metalloproteinase-9: The Significance of the Light-Dark Cycle in Metalloproteinase-9 in Acute Coronary Syndrome

Cinética de la metaloproteasa 9: importancia del ritmo luz-oscuridad de la metaloproteasa 9 en el síndrome coronario agudo

Alberto Domínguez-RodríguezaJuan C KaskibPedro Abreu-GonzálezcMartín J García-Gonzáleza

https://doi.org/10.1016/S1885-5857(08)60123-1

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2025 April	61	14	75
2025 March	72	14	86
2025 February	39	28	67
2025 January	48	26	74
2024 December	37	17	54
2024 November	36	16	52
2024 October	40	23	63
2024 September	64	20	84
2024 August	39	27	66
2024 July	18	13	31
2024 June	26	12	38
2024 May	26	6	32
2024 April	28	29	57
2024 March	20	17	37
2024 February	26	18	44
2024 January	22	22	44
2023 December	31	19	50
2023 November	37	15	52
2023 October	26	15	41
2023 September	23	12	35
2023 August	18	7	25
2023 July	23	20	43
2023 June	22	14	36
2023 May	26	11	37
2023 April	9	15	24
2023 March	15	12	27
2023 February	21	14	35
2023 January	15	18	33
2022 December	12	21	33
2022 November	26	15	41
2022 October	21	23	44
2022 September	31	22	53
2022 August	27	24	51
2022 July	15	25	40
2022 June	27	16	43
2022 May	21	25	46
2022 April	29	18	47
2022 March	30	26	56
2022 February	24	11	35
2022 January	13	22	35
2021 December	24	32	56
2021 November	26	17	43
2021 October	36	19	55
2021 September	19	20	39
2021 August	20	27	47
2021 July	23	20	43
2021 June	22	11	33
2021 May	33	17	50
2021 April	78	31	109
2021 March	58	28	86
2021 February	56	10	66
2021 January	39	10	49
2020 December	46	15	61
2020 November	34	15	49
2020 October	33	16	49
2020 September	14	7	21
2020 August	13	10	23
2020 July	37	16	53
2020 June	17	15	32
2020 May	36	13	49
2020 April	42	10	52
2020 March	16	6	22
2020 February	22	11	33
2020 January	20	13	33
2019 December	22	23	45
2019 November	20	4	24
2019 October	17	5	22
2019 September	26	21	47
2019 August	24	10	34
2019 July	31	24	55
2019 June	27	16	43
2019 May	25	13	38
2019 April	28	19	47
2019 March	43	13	56
2019 February	46	21	67
2019 January	46	11	57
2018 December	70	18	88
2018 November	34	13	47
2018 October	38	13	51
2018 September	22	4	26
2018 August	28	6	34
2018 July	55	9	64
2018 June	47	11	58
2018 May	38	9	47
2018 April	34	9	43
2018 March	37	8	45
2018 February	45	6	51
2018 January	36	6	42
2017 December	18	7	25
2017 November	14	4	18
2017 October	22	9	31
2017 September	22	8	30
2017 August	16	8	24
2017 July	13	2	15
2017 June	35	9	44
2017 May	23	7	30
2017 April	18	5	23
2017 March	24	2	26
2017 February	38	3	41
2017 January	36	2	38
2016 December	19	8	27
2016 November	24	6	30
2016 October	58	10	68
2016 September	152	7	159
2016 August	25	7	32
2016 July	38	11	49
2016 June	43	17	60
2016 May	38	24	62
2016 April	41	14	55
2016 March	31	11	42
2016 February	42	13	55
2016 January	37	21	58
2015 December	48	8	56
2015 November	37	15	52
2015 October	54	22	76
2015 September	54	15	69
2015 August	53	15	68
2015 July	34	11	45
2015 June	30	5	35
2015 May	48	10	58
2015 April	27	7	34
2015 March	38	7	45
2015 February	27	13	40
2015 January	19	7	26
2014 December	17	5	22
2014 November	19	9	28
2014 October	40	12	52
2014 September	18	3	21
2014 August	24	6	30
2014 July	28	13	41
2014 June	33	6	39
2014 May	29	9	38
2014 April	20	8	28
2014 March	52	12	64
2014 February	30	6	36
2014 January	46	13	59
2013 December	47	15	62
2013 November	50	12	62
2013 October	32	14	46
2013 September	39	20	59
2013 August	48	34	82
2013 July	49	25	74
2013 June	54	27	81
2013 May	52	48	100
2013 April	26	31	57
2013 March	25	12	37
2013 February	21	5	26
2013 January	17	8	25
2012 December	26	6	32
2012 November	17	11	28
2012 October	7	5	12
2012 September	847	0	847

To the Editor:

We have read with great interest the recent article of Rodríguez et al,1 in which the authors provide an excellent review of metalloproteinases (MMP) and atherothrombotic syndromes. However, we would like to make the following comments.

The inflammatory substrate implicated in acute coronary syndrome (ACS) is extremely complex and involves a number of factors related to both activation and modulation.2 MMP-9, in addition to playing a relevant role in the pathophysiology of the atherothrombotic process, may be useful as a biomarker of atherosclerotic risk and a predictor of recurrent coronary artery disease.3 Additionally, it has been observed that MMP-9 concentrations in patients with coronary artery disease are directly associated with inflammatory markers, such as C-reactive protein, interleukin 6, and fibrinogen.4 However, it has also been shown that certain factors, such as age, sex, dyslipidemia, diabetes, hypertension, and smoking, can influence MMP-9 concentrations.3

The scientific literature has described circadian variations in the circulating concentrations of some cytokines and acute phase reactants among patients with ACS.5-7 However, the existence of circadian variations in circulating MMP-9 concentrations has not been observed in healthy volunteers.8 Recent work by our group has shown diurnal variations in MMP-9 serum concentrations among patients with ACS.9 MMP-9 serum values were significantly higher during the light phase (at 9:00 AM) than the dark phase (at 2:00 PM), which indicates that the diurnal variability could, at least partly, have central neuroendocrine regulation, particularly with regard to melatonin, which is a circadian hormone.

MMP studies in patients with ACS offer considerable pathophysiological information regarding destabilization of the atherogenic process. Therefore, an extracellular matrix biomarker should be selected by standardizing the methods of measurement, establishing cutoff points to identify any values that clearly separate populations with different risks, and establishing how often and at what time of the day the blood samples should be drawn.10

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Metaloproteasas, remodelado vascular y síndromes aterotrombóticos..

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Tardif JC, Heinonen T, Orloff D, Libby P..

Vascular biomarkers and surrogates in cardiovascular disease..

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Ferroni P, Basili S, Martini F, Cardarello CM, Ceci F, di Franco M, et al..

Serum metalloproteinase 9 levels in patients with coronary artery disease: a novel marker of inflammation..

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Relation of nocturnal melatonin levels to C-reactive protein concentration in patients with ST-segment elevation myocardial infarction..

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http://dx.doi.org/10.1016/j.amjcard.2006.02.018 | Medline

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Domínguez Rodríguez A, Abreu González P, García González MJ, Ferrer J, de la Rosa A, Vargas M, et al..

Light/dark patterns of interleukin-6 in relation to the pineal hormone melatonin in patients with acute myocardial infarction..

Cytokine, (2004), 26 pp. 89-93

http://dx.doi.org/10.1016/j.cyto.2004.01.003 | Medline

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Domínguez Rodríguez A, Abreu González P, García MJ, de la Rosa A, Vargas M, Marrero F..

Ritmo luz/oscuridad de las citocinas proinflamatorias en el infarto agudo de miocardio..

Rev Esp Cardiol, (2003), 56 pp. 555-60

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Tayebjee MH, Lip GY, Blann AD, MacFadyen RJ..

Effects of age, gender, ethnicity, diurnal variation and exercise on circulating levels of matrix metalloproteinases (MMP)-2 and -9, and their inhibitors, tissue inhibitors of matrix metalloproteinases (TIMP)-1 and -2..

Thromb Res, (2005), 115 pp. 205-10

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Dominguez Rodriguez A, Abreu Gonzalez P, Garcia Gonzalez MJ, Reiter RJ..

Relation of nocturnal melatonin levels to serum matrix metalloproteinase-9 concentrations in patients with myocardial infarction..

Thromb Res, (2007), 120 pp. 361-6

http://dx.doi.org/10.1016/j.thromres.2006.10.010 | Medline

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Proteína C reactiva en el servicio de urgencias:¿ha encontrado una aplicación clínica? Rev Esp Cardiol, (2007), 60 pp. 797-800

https://doi.org/10.1016/S1885-5857(08)60123-1

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Year/month	Html	Pdf	Total
2025 May	27	6	33
2025 April	61	14	75
2025 March	72	14	86
2025 February	39	28	67
2025 January	48	26	74
2024 December	37	17	54
2024 November	36	16	52
2024 October	40	23	63
2024 September	64	20	84
2024 August	39	27	66
2024 July	18	13	31
2024 June	26	12	38
2024 May	26	6	32
2024 April	28	29	57
2024 March	20	17	37
2024 February	26	18	44
2024 January	22	22	44
2023 December	31	19	50
2023 November	37	15	52
2023 October	26	15	41
2023 September	23	12	35
2023 August	18	7	25
2023 July	23	20	43
2023 June	22	14	36
2023 May	26	11	37
2023 April	9	15	24
2023 March	15	12	27
2023 February	21	14	35
2023 January	15	18	33
2022 December	12	21	33
2022 November	26	15	41
2022 October	21	23	44
2022 September	31	22	53
2022 August	27	24	51
2022 July	15	25	40
2022 June	27	16	43
2022 May	21	25	46
2022 April	29	18	47
2022 March	30	26	56
2022 February	24	11	35
2022 January	13	22	35
2021 December	24	32	56
2021 November	26	17	43
2021 October	36	19	55
2021 September	19	20	39
2021 August	20	27	47
2021 July	23	20	43
2021 June	22	11	33
2021 May	33	17	50
2021 April	78	31	109
2021 March	58	28	86
2021 February	56	10	66
2021 January	39	10	49
2020 December	46	15	61
2020 November	34	15	49
2020 October	33	16	49
2020 September	14	7	21
2020 August	13	10	23
2020 July	37	16	53
2020 June	17	15	32
2020 May	36	13	49
2020 April	42	10	52
2020 March	16	6	22
2020 February	22	11	33
2020 January	20	13	33
2019 December	22	23	45
2019 November	20	4	24
2019 October	17	5	22
2019 September	26	21	47
2019 August	24	10	34
2019 July	31	24	55
2019 June	27	16	43
2019 May	25	13	38
2019 April	28	19	47
2019 March	43	13	56
2019 February	46	21	67
2019 January	46	11	57
2018 December	70	18	88
2018 November	34	13	47
2018 October	38	13	51
2018 September	22	4	26
2018 August	28	6	34
2018 July	55	9	64
2018 June	47	11	58
2018 May	38	9	47
2018 April	34	9	43
2018 March	37	8	45
2018 February	45	6	51
2018 January	36	6	42
2017 December	18	7	25
2017 November	14	4	18
2017 October	22	9	31
2017 September	22	8	30
2017 August	16	8	24
2017 July	13	2	15
2017 June	35	9	44
2017 May	23	7	30
2017 April	18	5	23
2017 March	24	2	26
2017 February	38	3	41
2017 January	36	2	38
2016 December	19	8	27
2016 November	24	6	30
2016 October	58	10	68
2016 September	152	7	159
2016 August	25	7	32
2016 July	38	11	49
2016 June	43	17	60
2016 May	38	24	62
2016 April	41	14	55
2016 March	31	11	42
2016 February	42	13	55
2016 January	37	21	58
2015 December	48	8	56
2015 November	37	15	52
2015 October	54	22	76
2015 September	54	15	69
2015 August	53	15	68
2015 July	34	11	45
2015 June	30	5	35
2015 May	48	10	58
2015 April	27	7	34
2015 March	38	7	45
2015 February	27	13	40
2015 January	19	7	26
2014 December	17	5	22
2014 November	19	9	28
2014 October	40	12	52
2014 September	18	3	21
2014 August	24	6	30
2014 July	28	13	41
2014 June	33	6	39
2014 May	29	9	38
2014 April	20	8	28
2014 March	52	12	64
2014 February	30	6	36
2014 January	46	13	59
2013 December	47	15	62
2013 November	50	12	62
2013 October	32	14	46
2013 September	39	20	59
2013 August	48	34	82
2013 July	49	25	74
2013 June	54	27	81
2013 May	52	48	100
2013 April	26	31	57
2013 March	25	12	37
2013 February	21	5	26
2013 January	17	8	25
2012 December	26	6	32
2012 November	17	11	28
2012 October	7	5	12
2012 September	847	0	847