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Vol. 70. Issue 6.
Pages 510-512 (June 2017)
Scientific letter
DOI: 10.1016/j.rec.2016.10.008
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Transcatheter Aortic Valve Implantation in Patients With Arterial Peripheral Vascular Disease
Implante percutáneo transfemoral de válvula aórtica en pacientes con enfermedad arterial periférica
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Leire Unzuéa,
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leireunzue@yahoo.es

Corresponding author:
, Eulogio Garcíaa, Rodrigo Teijeiroa, Miguel Rodríguez del Ríob, Jorge Solísa, Belén Rubio Alonsoa
a Servicio de Cardiología, Hospital Universitario Madrid Montepríncipe, Madrid, Spain
b Servicio de Anestesiología, Hospital Universitario Madrid Montepríncipe, Madrid, Spain
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Table. Baseline Clinical and Procedural Characteristics
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To the Editor,

Transcatheter aortic valve implantation (TAVI) via the transfemoral route appears to improve survival and cause fewer complications than transapical implantation. Whenever possible, the transfemoral route should therefore be the first choice.1

Developments to facilitate peripheral access include the use of a contralateral guidewire2 and the smaller profile and improved navigability of the new introducers. Together with increased operator experience, these advances have improved procedure safety and reduced the number and severity of vascular complications.3

The range of patients who can benefit from transfemoral TAVI has been extended by progressive reductions in the delivery system profile. However, in a high proportion of patients, the peripheral access route is below the minimum 5.5mm diameter. These peripheral vascular disease patients often have comorbidities that increase surgical risk,4 and consequently are either excluded from surgery or undergo intervention associated with a very high mortality rate.5 This high risk profile makes transfemoral TAVI an especially attractive strategy in these patients.

Here, we describe our experience with transfemoral TAVI in patients with severe peripheral vascular disease and artery access diameter < 5.5 mm. A series of 57 consecutive patients underwent transfemoral TAVI with an expandable balloon prosthesis (Edwards-SAPIEN XT in the first 9 patients and Edwards-SAPIEN 3 in the remaining 48).

In total, 7 patients undergoing transfemoral TAVI had arterial access < 5.5 mm (12.3%). All 7 patients had major comorbidities, and 4 had a history of heart surgery. The mean EuroSCORE for these patients was 14.1±11.1 (Table).

Table.

Baseline Clinical and Procedural Characteristics

 
Age, y  79  84  78  77  73  81  79 
Sex  M  M  M 
EuroSCORE (%)  19.6  6.8  14.2  7.7  36.4  7.3  6.4 
Peripheral vascular disease  Yes  Yes  Yes  Trouser-like iliac stenting  Yes  No  Yes 
Minimum femoral diameter, mm  4.3  4.7  4.8  2.4  3.8  5.5 
Calcification score (1-4) 
Previous heart surgery  Yes  Yes  Yes  No  Yes  No  No 
Valve type  S3  S3  S3  S3  S3  XT  XT 
Size  23  23  26  26  23  26  29 
Sheath (Fr)  14  14  14  14  14  18  20 
Complications  Advanta stent  No  No  No  TIA  No  No 

F, female; Fr, French; M, male; S3, Edwards-SAPIEN 3 prosthetic valve; TIA, transitory ischemic accident; XT, Edwards-SAPIEN XT prosthetic valve.

In all patients except 1, a guidewire was introduced from the contralateral femoral artery, as described previously.2 In 4 patients, balloon angioplasty was carried out at the start of the procedure at the level of the left or right common iliac artery; the procedure was performed with an 8×40mm Wanda balloon (Boston Scientific, Ratingen, Germany) in 3 patients and with a nonexpandable 5×15mm Euphora balloon (Medtronic) in the other patient.

In 3 patients, we also took advantage of the dynamic expansion mechanism available with the Edwards eSheath and the Novaflex + delivery system: the whole system was withdrawn to a region of wider diameter as the valve was advanced, allowing introduction of the delivery system through the narrower segment.

In 1 patient with severe peripheral vascular disease and trouser-like stenting at the iliac bifurcation, the distal iliac border of the stent was supported by balloon angioplasty during sheath introduction (Figure). In all patients, percutaneous closure was achieved with the Prostar XL system (Abbott Vascular; Santa Clara, California, United States). In 1 patient, active bleeding was observed at the end of the procedure; the failure of the Prostar XL system in this patient was likely due to large-scale vessel calcification impeding wound suturing. The hemorrhage resolved immediately upon implantation of a 10×38mm Advanta v12 polytetrafluoroethylene-coated stent (Atrium Medical Corp; Hudson, New Hampshire, United States). In another patient, with moderate bleeding, internal hemostasis was restored by prolonged inflation of the balloon used for predilation. In all patients, outcome was monitored by angiography from the contralateral femoral artery. There were no major intraprocedural complications, and patients were discharged from hospital 3.5±4.3 days after the procedure.

Figure.

Implantation of an aortic valve prosthesis in a patient with peripheral vascular disease and trouser-like stenting at the iliac bifurcation. A: initial right femoral angiography. B: balloon angioplasty at the distal iliac border of the stent. C: collision of the introducer sheath with the distal-most extreme of the right iliac stent (arrow). D: buddy balloon technique for sheath introduction. E and F: valve introduction into the abdominal aorta.

(0.35MB).

In the only previous report of transfemoral TAVI with narrow femoral access, predilation was used in 17 patients, resulting in 6 cases of iliac dissection.6 In our series, there were no dissections; however, this might reflect the predominant use of the latest generation Edwards-SAPIEN 3 prosthesis, which is introduced through a narrow-bore and highly compliant sheath. When treating patients with difficult femoral access, contralateral guidewire placement is essential to ensure immediate and effective access in the event of complications.

With appropriate planning and familiarity with established percutaneous techniques, transfemoral TAVI is a safe and effective procedure in patients with small diameter femoral access.

References
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Immediate and intermediate outcome after transapical versus transfemoral transcatheter aortic valve replacement.
Am J Cardiol., 117 (2016), pp. 245-251
[2]
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Usefulness of placing a wire from the contralateral femoral artery to improve the percutaneous treatment of vascular complications in TAVI.
Rev Esp Cardiol., 67 (2014), pp. 410-412
[3]
C. Sari, H. Ayhan, A.N. Aslan, T. Durmaz, T. Keleş, S. Baştuğ.
Predictors and incidence of access site complications in transcatheter aortic valve implantation with the use of new delivery systems.
Perfusion., 30 (2015), pp. 666-674
[4]
M.H. Criqui, J.K. Ninomiya, D.L. Wingard, M. Ji, A. Fronek.
Progression of peripheral arterial disease predicts cardiovascular disease morbidity and mortality.
J Am Coll Cardiol., 52 (2008), pp. 1736-1742
[5]
S.R. Kapadia, E.M. Tuzcu, R.R. Makkar, L.G. Svensson, S. Agarwal, S. Kodali.
Long-term outcomes of inoperable patients with aortic stenosis randomly assigned to transcatheter aortic valve replacement or standard therapy.
Circulation., 130 (2014), pp. 1483-1492
[6]
N. Ruparelia, N. Buzzatti, V. Romano, M. Longoni, F. Figini, M. Montorfano.
Transfemoral transcatheter aortic valve implantation in patients with small diseased peripheral vessels.
Cardiovasc Revasc Med., 16 (2015), pp. 326-330
Copyright © 2016. Sociedad Española de Cardiología
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