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Vol. 67. Issue 3.
Pages 203-210 (March 2014)
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Vol. 67. Issue 3.
Pages 203-210 (March 2014)
Special article
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Update in Cardiology: Vascular Risk and Cardiac Rehabilitation
Temas de actualidad en cardiología: riesgo vascular y rehabilitación cardiaca
Enrique Galvea,
Corresponding author

Corresponding author: Servicio de Cardiología, Hospital Vall d’Hebron, Pg. Vall d’Hebron 119, 08035 Barcelona, Spain.
, Eduardo Alegríab, Alberto Corderoc, Lorenzo Fácilad, Jaime Fernández de Bobadillae, Carla Lluís-Ganellaf, Pilar Mazóng, Carmen de Pablo Zarzosah, José Ramón González-Juanateyg
a Servicio de Cardiología, Hospital Vall d’Hebron, Barcelona, Spain
b Servicio de Cardiología, Policlínica Gipuzkoa, San Sebastián, Guipúzcoa, Spain
c Departamento de Cardiología, Hospital Universitario de San Juan, Sant Joan d’Alacant, Alicante, Spain
d Servicio de Cardiología, Consorcio Hospital General de Valencia, Valencia, Spain
e Servicio de Cardiología, Hospital La Paz, Madrid, Spain
f Grupo de Epidemiología y Genética Cardiovascular, IMIM (Institut Hospital del Mar d’Investigacións Mèdiques), Barcelona, Spain
g Servicio de Cardiología, Hospital Universitario de Santiago de Compostela, Santiago de Compostela, A Coruña, Spain
h Servicio de Cardiología, Hospital Ramón y Cajal, Madrid, Spain
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Tables (3)
Table 1. Targets Reached in Each of the Recommendations of the Guidelines for Patients With Coronary Heart Disease, According to the EUROASPIRE IV Study
Table 2. Indications for Bariatric Surgery (2013)
Table 3. Ongoing Clinical Trials With Incretin-based Therapies
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Cardiovascular disease develops in a slow and subclinical manner over decades, only to manifest suddenly and unexpectedly. The role of prevention is crucial, both before and after clinical appearance, and there is ample evidence of the effectiveness and usefulness of the early detection of at-risk individuals and lifestyle modifications or pharmacological approaches. However, these approaches require time, perseverance, and continuous development. The present article reviews the developments in 2013 in epidemiological aspects related to prevention, includes relevant contributions in areas such as diet, weight control methods (obesity is now considered a disease), and physical activity recommendations (with warnings about the risk of strenuous exercise), deals with habit-related psychosocial factors such as smoking, provides an update on emerging issues such as genetics, addresses the links between cardiovascular disease and other pathologies such as kidney disease, summarizes the contributions of new, updated guidelines (3 of which have recently been released on topics of considerable clinical importance: hypertension, diabetes mellitus, and chronic kidney disease), analyzes the pharmacological advances (largely mediocre except for promising lipid-related results), and finishes by outlining developments in the oft-neglected field of cardiac rehabilitation. This article provides a briefing on controversial issues, presents interesting and somewhat surprising developments, updates established knowledge with undoubted application in clinical practice, and sheds light on potential future contributions.

Risk factors
Physical exercise
Diabetes mellitus

La enfermedad cardiovascular se establece de manera lenta y subclínica durante décadas, para a menudo manifestarse de modo abrupto e inesperado. El papel de la prevención, antes y después de la aparición de la clínica, es capital y existen numerosas pruebas de la eficacia y la eficiencia de las medidas dirigidas a detectar precozmente a los sujetos en riesgo y actuar mediante modificaciones en el estilo de vida o medidas farmacológicas, pero ello exige tiempo, constancia y actualización permanente. Este artículo resume las novedades de 2013 en los aspectos epidemiológicos relacionados con la prevención, incorpora relevantes contribuciones en materias como la dieta, las formas de control del peso (la obesidad ha pasado a ser considerada una enfermedad) y las recomendaciones sobre la actividad física (con advertencias sobre el riesgo del ejercicio extenuante), aborda los factores psicosociales tan relacionados con hábitos como el tabaquismo, actualiza aspectos emergentes como la genética, trata el ligamen de la enfermedad cardiovascular con otras como la renal, resume la aportación de nuevas guías que actualizan las previas (han visto la luz muy recientemente tres de ellas sobre aspectos de gran peso clínico: hipertensión, diabetes mellitus y enfermedad renal crónica) y analiza los avances farmacológicos, ciertamente no espectaculares, pero algunos, como en lípidos, prometedores, para acabar poniendo al día el siempre olvidado campo de la rehabilitación cardiaca. La lectura de esta actualización pone al día temas controvertidos, aporta novedades de interés y algunas sorprendentes, sedimenta viejos conocimientos de indudable aplicación en el ejercicio clínico y abre las puertas a aportaciones de futuro.

Palabras clave:
Puesta al día
Factores de riesgo
Ejercicio físico
Hipertensión arterial
Diabetes mellitus
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Cardiovascular disease (CVD) is a major cause of disability, substantially increases health care costs, and is the most common cause of death in developed countries. One of the most important health care activities is cardiovascular (CV) prevention, whether primary or secondary (the latter being closely linked to cardiac rehabilitation). CV prevention shows clear benefits, and has contributed to a notable reduction in CV morbidity and mortality in developed countries in recent decades. Nonetheless, much work remains to be done, as shown by data on the so-called residual risk, and the achievements made fail to mask patent deficiencies in numerous areas.1–3

The current article examines in depth the most notable developments of the last year, critically analyzing and summarizing recent results and serving as a comprehensive although not exhaustive update on these topics.


Although atherosclerotic CVDs are the main cause of death worldwide,2 this group of diseases have known risk factors that can be tackled by prevention.

In 2012, the latest European guidelines on CV prevention were published.3 While the guidelines continue to recommend the use of the SCORE scale for risk stratification, they include some changes and make various recommendations to achieve the targets for the different risk factors, focusing on lifestyle interventions and cardioprotective drug use. All patients should reach these targets, but that goal is far from being met, which is why knowledge of the degree of guideline implementation is essential. Accordingly, results from the EUROASPIRE IV study were presented at the recent European Society of Cardiology (ESC) meeting. This study was performed in 24 European countries to determine whether the recommendations of the latest guidelines are being followed in patients with established coronary heart disease and whether prevention has improved compared with the EUROASPIRE I, II, and III surveys.1

Reports were collected on 13 500 coronary patients, 49% of whom were interviewed. Only those younger than 80 years that had had an event between 6 months and 3 years before the interview were selected. Only 51% of smokers ceased smoking, although the percentage was 73% in Spain; 82% were overweight, a third were obese, and half had abdominal obesity. Moreover, only 41% participated in some type of prevention program. The participation rate did increase to 81% in those who were notified of the existence of the program, but only half had been informed.

A higher than recommended blood pressure (BP) was shown by 43% of patients (by 40% in Spain); 25% were unaware that they were hypertensive, and only 53% of those receiving treatment reached the BP targets. The lipids of 2 out of every 3 patients were not controlled, and 81% had a low-density lipoprotein (LDL) cholesterol level above 70mg/dL. Spain showed the best lipid control, in 59% of patients. Although 87% of patients in the survey were being treated with lipid-lowering drugs, only 21% of these were controlled. An average of 27% of the patients (or 33% in Spain) was diabetic. Another 13% had a fasting blood glucose level > 126mg/dL and, of these, 47% had a glycated hemoglobin hba level above 7%.

Therefore, according to this study, most coronary patients do not achieve their risk factor control targets (Table 1), even those undergoing treatment, and in turn half are not aware of the presence of these risk factors or of their levels, suggesting inadequate treatment and control. Nonetheless, the percentage of patients receiving the recommended treatments was high: anticoagulants were being taken by 94%, statins by 86%, beta-blockers by 83%, and angiotensin-converting enzyme inhibitors or angiotensin receptor blockers 75%. In sum, not only is risk factor control poor, but also improvements are not seen.

Table 1.

Targets Reached in Each of the Recommendations of the Guidelines for Patients With Coronary Heart Disease, According to the EUROASPIRE IV Study

Guideline recommendation  Targets reached, % 
Smokers that quit smoking  51 
Body mass index
< 25  18 
< 30  62 
Waist circumference
Men < 102 cm  47 
Women < 88 cm  25 
Blood pressure  57
< 140/90 mmHg 
(< 140/80 mmHg in DM) 
LDL-C < 70 mg/dL  19 
DM-HbA1c< 7%  53 
Antiplatelet agents  94 
Beta-blockers  83 
Statins  86 
ACE inhibitors/ARB  75 

ACE, angiotensin-converting enzyme; ARB, angiotensin receptor blockers; LDL-C, low-density lipoprotein cholesterol; DM, diabetes mellitus; HbA1c, glycated hemoglobin.

In the PURE study,4 performed in a cohort of 154 000 patients with history of coronary heart disease or stroke in 17 countries, the prevalence of healthy lifestyles was low, with only half quitting smoking, 19% still smoking, and just 39% and 35% with a suitable diet and level of physical activity, respectively. Although these percentages are increasing in developed countries, they remain below 50%.

In Spain, the ENRICA5 study found adequate blood cholesterol control in 43% of patients with previous CVD. A registry of the Barbanza group6 also showed poor risk factor control in 1108 patients with chronic ischemic heart disease, with data even worse than those of the EUROASPIRE study. Lower percentages of cardioprotective drug use were seen, with the exception of lipid-lowering drugs, which reached 88%.

Clearly, the data indicate the need for comprehensive and multidisciplinary prevention programs in both patients and their families, and, fundamentally, an integrated organizational model of primary and specialized care.


The most relevant diet-related contribution has been provided by the PREDIMED. The Spanish authors of this study demonstrated that a Mediterranean diet with olive oil reduced the incidence of serious CV complications by 30% in individuals at high CV risk.7 Another Spanish study, HELENA, showed that the dietary consumption of dairy is associated with lower levels of adiposity and greater cardiorespiratory fitness in adolescents.8 A meta-analysis seemed to clear egg consumption of contributing to CV risk.9 Finally, the serious impact was reiterated of artificial sweeteners and artificial sweetener-containing drinks on CV risk.10

The decision of the American Medical Association to consider obesity a disease (June 2013) sparked controversy.11 Fat distribution was confirmed to influence CV risk more than weight itself.12 The lack of efficacious and safe drugs that combat obesity was confirmed once more.13,14 Thus, attention has returned to functional foods (enriched in substances that can improve health).15 The indications for bariatric surgery have been expanded (Table 2), following technical improvements and better results.16–18 As a logical consequence of the magnitude and importance of obesity, a number of initiatives have been undertaken to combat it, some in Spain.19

Table 2.

Indications for Bariatric Surgery (2013)

BMI ≥ 40 kg/m2 
• If the surgical risk is acceptable 
BMI ≥ 35 kg/m2 
• If there is more than one obesity-related comorbidity: 
Type 2 DM, HT, dyslipidemia 
Obstructive sleep apnea, obesity-hypoventilation, and Pickwickian syndromes 
Nonalcoholic fatty liver disease 
Idiopathic intracranial hypertension (pseudotumor cerebri) 
Gastroesophageal reflux disease 
Venous stasis disease 
Significant urinary incontinence 
Debilitating arthropathy 
BMI 30 to 34.9 kg/m2 
With DM or metabolic syndrome (insufficient long-term data) 

BMI, body mass index; DM, diabetes mellitus; HT, hypertension.

New evidence has shown the efficacy of exercise in fighting CV complications. For example, people who exercise enough to sweat at least 4 times a week have a 20% lower risk of stroke than sedentary individuals.20 There were also warnings about the risks of strenuous exercise.21 Notably, barely half of Catalan physicians take enough exercise (in addition, 20% smoke); worse is that 60% of male physicians are overweight (compared with 18% of female physicians).22


The most vulnerable social groups are those that are most affected by smoking. In the last year, the numbers of homeless have increased due to the economic crisis, and there are now more than 2 million homeless in the United States. Over 75% of homeless people smoke, and they struggle to quit smoking due to their high prevalence of psychiatric illnesses and psychological factors, such as their placement of a higher value on immediate than deferred rewards23; a similar situation occurs in older persons, another expanding social group.24

Regarding technological advances, mobile phone applications25 and internet groups26 are useful for quitting smoking. The electronic cigarette has conquered the market in the United States, but its regulator has no powers because the manufacturers have not claimed a therapeutic effect, which is what occurred with conventional cigarettes at the start of the 20th century. It should be the nature of the product and not the maker that determines its regulation by a given body. Thus, electronic cigarettes should be regulated by the European Medicines Agency in Europe and the Food and Drug Administration in the United States.27 Meanwhile, health care professionals should discourage their use.

Although varenicline is the most effective drug for smoking cessation, together with either counseling or behavioral therapy,28 the drug has been linked to depression. However, a recent study showed that varenicline can be safely used even when there is a history of depression.29

Social influence is critical in young people. Having friends or a partner who smokes is the most decisive factor in starting smoking.30 Preventing smoking from being seen as something routine would prevent many from becoming addicted. In July 2013, the Public Health Committee of the European Parliament approved a resolution aimed at stopping the tobacco industry from recruiting smokers from young people. The ESC and the Spanish Society of Cardiology support these initiatives, but the influence of cardiologists on smoking is still weak.31 Nonetheless, these measures are not fruitless: in the first year that the antismoking laws came into force in Spain, the incidence of acute myocardial infarction fell dramatically (Figure 1).32

Figure 1.

Changes in the incidence of acute myocardial infarction in Spain from 2002 to 2011. Within an overall decreasing trend, notable decreases are seen between the years 2005 to 2006 and 2010 to 2011, coinciding with the introduction of each antismoking law. AMI, acute myocardial infarction. Reproduced from Fernández de Bobadilla et al.,32 with permission.


The developments in lipids have revolved around 2 key points: the suspension of the HPS2-THRIVE study,33 with the consequent withdrawal of niacin, and the enormous expectation generated by drugs that inhibit PCSK9 (proprotein convertase subtilisin/kexin type 9). In the case of the former, the safety committee of the HPS2-THRIVE1 study decided to prematurely end this trial due to a lack of efficacy and, more alarmingly, an increase in the incidence of serious secondary effects. The study randomly assigned patients with a history of symptomatic CVD (myocardial infarction, cerebrovascular disease, or peripheral arterial disease) undergoing statin treatment to receive either niacin plus laropiprant (2 g + 40 mg/24 h) or placebo. The suspension of the study at a mean follow-up of 3.6 years was largely due to the higher rate of treatment termination for medical reasons in the niacin group (25.4% vs 16.6%; P < .01), and increased incidences of diabetes mellitus (0.9% vs 0.4%; P < .01) and myopathies (1.8% vs 1.0%; P < .01). Study termination was accompanied by commercial withdrawal of the drug, which reignited the debate about which is the best adjunctive strategy to statin treatment. In February 2013, an update was published to the Canadian guidelines for the treatment of dyslipidemia, which continue to support treatment with statin monotherapy, at the highest tolerated dose, and does not recommend any specific combination with statins.34

The other pharmacological strategy has garnered considerable interest: monoclonal antibodies against PCSK9, a protease that binds to the liver receptor of LDL and promotes its degradation; these monoclonal antibodies inhibit this binding action and reduce the turnover of the LDL liver receptors, increasing LDL uptake and elimination and eventually reducing its serum concentration. This therapeutic strategy has 3 key novel points compared with statins: a) its mechanism of action does not involve cholesterol synthesis, which is why it does not show the secondary hepatic and muscular effects of statins; b) it is administered subcutaneously, and c) it is administered every 2 to 4 weeks. In the annual meeting of the American College of Cardiology in March 2013, more than 7 studies were presented that showed an LDL-reducing efficacy of between 40% and 60% (Figure 2); some of these studies have already been published.35,36 Mid-way through 2013, clinical trials were started that randomize high-risk CV patients to these treatments or to placebo, which will enable determination of the real clinical benefit of this promising lipid-lowering strategy.

Figure 2.

Reduction in the serum values of low-density lipoprotein cholesterol and apoB with different doses and durations of monoclonal antibodies against PCSK9. ApoB, apolipoprotein B; LDL-C, low-density lipoprotein cholesterol; Lp (a), lipoprotein (a).


Two developments stand out. First, the publication of a prediction score for contrast-induced nephropathy37 that involves 15 of the 46 variables most closely linked to the development of contrast-induced nephropathy in patients undergoing an intervention37,38 (available online at, which helps the selection of those that would benefit from prophylaxis. KDIGO39 guidelines for chronic kidney disease also appeared, which continue to recommend the use of the glomerular filtration rate as a fundamental indicator of renal function. The main change has been the modification of the classification of kidney disease; although 5 levels remain, level 3 has been subdivided into 3a and 3b (higher or lower than 45mL/min) and various levels have been added according to albuminuria status (A1, A2, and A3). The term albuminuria should be used instead of microalbuminuria, and all patients should be referred to a specialist when the glomerular filtration rate is < 30mL/min/1.73 m2, albuminuria is > 300mg/day, albumin/creatinine ratio in urine is > 300mg/g, or proteinuria > 500mg/d.


The most important development has been the new European Society of Hypertension/ESC guidelines.40 Although there are few modifications with respect to the 2007 to 2009 guidelines, some changes should be noted. On the one hand, the therapeutic target has been simplified, homogenizing the systolic BP for the entire population at < 140 mmHg. Exceptions are made for older people and those with diabetes mellitus or kidney disease. For diagnosis, the guidelines highlight the growing importance of ambulatory BP monitoring compared with clinical office measurement. The guidelines also reconfirm that the 5 pharmacological therapy groups can be used, and should be selected bearing in mind the patient's comorbidities; these groups include beta-blockers, whose use has sometimes been doubted. Regarding drug combinations, diuretics with angiotensin-converting enzyme inhibitors, angiotensin receptor blockers, or calcium antagonists are preferred, as well as angiotensin-converting enzyme inhibitors or angiotensin receptor blockers with calcium antagonists, which is a modification of the classic approach.40

Two meta-analyses were published on the effects of reducing salt consumption.41,42 Decreased salt ingestion was associated with a fall in BP, but not with a reduction in CV morbidity and mortality, which means that the clinical recommendation concerning low sodium diets in hypertensive individuals should probably be less forceful.

In Spain, 2 studies stand out. One study into renal denervation concluded that this technique, implemented via a multidisciplinary program and a proper patient selection protocol, offers an improvement in BP that is similar to that of previous studies, with a greater reduction than that produced by antihypertensive drugs and higher efficacy.43 The second study refers to the data of the PRESCAP study, which showed that hypertension control noticeably improved in Spain between 2002 and 2010, coinciding with a greater use of drug combinations.44


Recent trials have shown that diverse lipid-lowering strategies are safe but ineffective in reducing CV events. Thus, the Look AHEAD Research Group study,45 an intensive weight-loss intervention, did not show differences in events, despite achieving reductions in weight, BP, and glycated hemoglobin. In the ORIGIN study,46 insulin glargine had no effect on CV events and cancer development, although it caused more hypoglycemia and a slight weight gain. In the SAVOR-TIMI 5347 and EXAMINE48 studies, conducted with the dipeptidyl peptidase 4 inhibitors saxagliptin and alogliptin, respectively, there was no disimprovement in CV events, although neither was there a reduction. Hospitalization from heart failure was more frequent with saxagliptin (P = .007). Although the difference in glycated hemoglobin between the groups was significant, the decrease was slight. Various trials are ongoing with glucagon-like peptide-1 analogues and dipeptidyl peptidase 4 inhibitors (Table 3).

Table 3.

Ongoing Clinical Trials With Incretin-based Therapies

Drug (trial)  Primary objective  Patients, no.  Start-end 
Dipeptidyl peptidase 4 inhibitors
Sitagliptin (TECOS)  Cardiovascular death, infarction, stroke, or hospitalization for unstable angina  14 000  12/2008-12/2014 
Linagliptin (CARMELINA)  Cardiovascular death, infarction, stroke, or hospitalization for unstable angina  8300  7/2013-1/2018 
Linagliptin vs glimepiride (CAROLINA)  Cardiovascular death, infarction, stroke, or hospitalization for unstable angina  6000  10/2010-9/2018 
Glucagon-like peptide-1 analogues
Daily lixisenatide (ELIXA)  Cardiovascular death, infarction, stroke, or hospitalization for unstable angina  6000  6/2010-8/2014 
Daily liraglutide (LEADER)  Cardiovascular death, infarction, or stroke  9340  8/2010-1/2016 
Weekly exenatide (EXSCEL)  Cardiovascular death, infarction, or stroke  9500  6/2010-3/2017 
Weekly dulaglutide (REWIND)  Cardiovascular death, infarction, or stroke  9622  6/2011-4/2019 
Weekly taspoglutide  Cardiovascular death, infarction, or stroke  2118  1/2010-? 

Studies of the hypoglycemic peroxisome proliferator-activated receptors alpha and gamma agonist aleglitazar have been halted due to safety concerns, although the final results remain to be published.

The ESC and European Association for the Study Of Diabetes have published new guidelines on diabetes, prediabetes, and CVD. Because the complete translation will be published in Revista Española de Cardiología49 in conjunction with comments from the point ofview of Spanish cardiology, only the most relevant points will be summarized here: a) the investigational algorithm is maintained for both patients with CVD, with or without diabetes, and those diagnosed with diabetes mellitus, with or without heart disease, although the indications are not addressed with recommendation levels or level of evidence but with a general approach that should be individualized in each case; b) the detection of ischemia in asymptomatic diabetic patients is a class IIb level C indication; c) the diagnosis of diabetes mellitus is based on the glycated hemoglobin value or on the basal fasting glucose level, and the oral glucose tolerance test is reserved for questionable cases; d) the use of classical scoring methods for calculating risk is discouraged as all diabetics are considered to have high CV risk; e) the risk factor control targets and coronary revascularization strategies are the other recent guidelines of the ESC, and the use of acetylsalicylic acid in primary prevention is discouraged, and f) the glycated hemoglobin target is less stringent (in general, < 7%), but there is little information on the use of hypoglycemic agents in CVD.


The last few years have shown huge developments in the understanding of the genetics of monogenic diseases, in which the presence of certain genetic variants in one or several is usually sufficient for disease appearance, and some genetic tests are even used in routine clinical practice.50 In contrast, for complex diseases such as ischemic heart disease, which are more frequent and associated with numerous genetic variants (polymorphisms) as well as environmental factors, gene identification has been less fruitful. Genome-wide association studies51 have identified 45 polymorphisms associated with ischemic heart disease, some of which are also associated with LDL cholesterol, hypertension, and inflammation, which confirms the importance of these factors in the pathogenesis of this disease.52

The translation of this knowledge into clinical practice and prevention is complex (Figure 3), but genetic analysis could have the following applications53: a) identification of new therapeutic targets in the treatment of hypercholesterolemia, such as antibodies against PCSK9 protein54; b) analysis of the causality of the association between biomarkers and diseases through Mendelian randomization studies, which have questioned the causal relationship between high-density lipoprotein cholesterol and ischemic heart disease55; c) improvement in the predictive ability of risk functions using genetic information, signaling their potential clinical usefulness for intermediate-risk individuals,56,57 and d) CV pharmacogenomics,58 although the results remain inconclusive. A good example of the latter is clopidogrel, a drug whose efficacy shows high interindividual variability, which has been associated in some studies with genetic variants in the CYP2C19 gene. Although the Food and Drug Administration has warned that its efficacy could depend on the patient's genetic characteristics, the American scientific societies published a consensus stating that the clinical usefulness of the genetic tests remains to be established.59 Recent meta-analyses have shown that the association is seen in studies with small sample sizes60 and have concluded that the evidence does not support the use of individualized doses of the drug according to CYP2C19 genotype.

Figure 3.

Steps in the study of genetic variants and some of their uses.


For the first time, the latest European guidelines on CV prevention3 contain a specific section on cardiac rehabilitation programs, which are considered a cost-effective approach to risk reduction following an acute coronary event because they improve prognosis and reduce hospitalizations and medical care costs, as well as prolong life. Cardiac rehabilitation after a CV episode is a class I recommendation of the ESC, the American Heart Association, and the American College of Cardiology.61,62 The new ESC clinical practice guidelines on the management of acute coronary syndrome with ST-segment elevation63 also insist on a class I indication for these programs, attaching considerable importance to the early initiation of secondary prevention measures as a way to maintain long-term adherence. In both guidelines, reference is made to the early management of psychological factors, such as stress, anxiety, and depression, and they recommend patient evaluation and appropriate treatment before hospital discharge.

New publications and a recent meta-analysis continue to show decreased morbidity and mortality through the use of these programs.64,65 However, the participation rate is low for various reasons, and strategies have been employed to improve access. A recent review stressed the need for mechanisms that automatically refer patients to rehabilitation after hospital discharge. This review also stresses the need to show health care professionals, physicians, and nonphysicians the clinical aspects and benefits of these programs.66,67 The number of prevention and cardiac rehabilitation programs in Spain is still low, and they are poorly distributed in certain regions. In recent years, some autonomous communities, such as Andalusia, the Basque Country, and the Community of Madrid, have endeavored to create new units or to increase the number of existing places to improve access to the population. However, in other regions there are no cardiac rehabilitation programs in the public health care setting. There are multiple causes for this lack of development, including the minimal support of the administrations, the economic situation, and the scant interest shown by cardiologists in some aspects of CV prevention, which is perhaps the most grievous. The Vascular Risk and Cardiac Rehabilitation Section of the Spanish Society of Cardiology is creating a register of the existing cardiac rehabilitation units, both public and private. This register will reflect the current situation and regional differences and will spur the creation of new units that improve patient access to these secondary prevention programs of proven value.

The basic components and objectives of cardiac rehabilitation have been standardized over many years, although their structures vary from one country to another. Various programs can be found, including residential, hospital-based, and home-based programs, as well as those localized in specialized units and primary care centers,68 with different levels of supervision.69 A recent review confirmed the benefits of home-based programs in low-risk patients, with results similar to those of traditional programs. Also praised were the use of new technologies (telephone, web, and videoconferencing) to improve patient access, resolving problems associated with distance, time, and compatibility with work.

Efforts should be made to maintain long-time compliance. The duration and intensity of the intervention, in addition to the participant's motivation of the participant, have been correlated with an improved prognosis. The possibility of strengthening the intervention in the long-term after a standard rehabilitation program would improve adherence. New technologies could have a prominent role in this aspect of the approach.


Vascular risk factors are of interest to all health care levels and have a social impact, because they also affect the general population. The present update indicates that while major drug trials offer results of little value, attention is shifting to classical aspects, such as lifestyle changes, because much work remains to be done in these areas, physicians can influence all segments of the population and the regulatory authorities, and the data are already available, as is happening with antismoking legislation. Marshaling the help of the skilled and available nursing staff is crucial in these tasks, particularly in health education, and, with the incorporation of telemedicine, could provide superior cost-effectiveness.

On a separate issue, consensus documents continue to appear and be updated, although the poor achievement of the indicated targets should give pause for thought. Even though drug therapy developments may be slowing, alternative interventions are appearing, from renal denervation to bariatric surgery, while new approaches fight to find a space, such as those connected to the genetic world. In the health care environs, new communication technologies between doctor, device, and patient are steadily emerging. The translation of all these approaches into improved general prevention remains a challenge.


None declared.

K. Kotseva, D. Wood, G. De Backer, D. De Bacquer, K. Pyorala, U. Keil.
Cardiovascular prevention guidelines in daily practice: a comparison of EUROASPIRE I, II and III surveys in eight European countries.
Lancet, 14 (2009), pp. 929-940
World Health Statistics 2013.
WHO, (2013),
J. Perk, G. De Backer, H. Gohlke, I. Graham, Z. Reiner, M. Verschuren, et al.
Guía europea sobre prevención de la enfermedad cardiovascular en la práctica clínica (versión 2012). Quinto grupo de trabajo de la Sociedad Europea de Cardiología y otras Sociedades sobre la Prevención de la Enfermedad Cardiovascular en la Práctica Clínica (constituido por representantes de nueve sociedades y expertos invitados). Desarrollada con la contribución especial de la Sociedad Europea de Prevención y Rehabilitación Cardiovascular.
Rev Esp Cardiol, 65 (2012), pp. e1-e66
K. Teo, S. Lear, S. Islam, P. Mony, M. Dehghan, W. Li, et al.
Prevalence of a healthy lifestyle among individuals with cardiovascular disease in high-, middle- and low-income countries. The Prospective Urban Rural Epidemiology (PURE) Study.
JAMA, 309 (2013), pp. 1613-1621
P. Guallar-Castillón, M. Gil-Montero, L.M. León-Muñoz, A. Graciani, A. Bayán-Bravo, J.M. Taboada, et al.
Magnitud y manejo de la hipercolesterolemia en la población adulta de España, 2008-2010: el estudio ENRICA.
Rev Esp Cardiol, 65 (2012), pp. 551-558
R. Vidal-Perez, F. Otero-Raviña, M. Franco, J.M. Rodríguez Garcia, R. Liñares Stolle, R. Esteban Alvarez, BARBANZA investigators, et al.
Determinants of cardiovascular mortality in a cohort of primary care patients with chronic ischemic heart disease. BARBANZA Ischemic Heart Disease (BARIHD) study.
Int J Cardiol, 167 (2013), pp. 442-450
R. Estruch, E. Ros, J. Salas-Salvadó, M.I. Covas, D. Corella, F. Arós, PREDIMED Study Investigators, et al.
Primary prevention of cardiovascular disease with a Mediterranean diet.
N Engl J Med, 368 (2013), pp. 1279-1290
S. Bel-Serrat, T. Mouratidou, D. Jiménez-Pavón, I. Huybrechts, M. Cuenca-García, L. Mistura, HELENA study group, et al.
Is dairy consumption associated with low cardiovascular disease risk in European adolescents? Results from the HELENA study.
Y. Rong, L. Chen, T. Zhu, Y. Song, M. Yu, Z. Shan, et al.
Egg consumption and risk of coronary heart disease and stroke: dose-response meta-analysis of prospective cohort studies.
BMJ, 346 (2013), pp. e8539
G.A. Bray, B.M. Popkin.
Calorie-sweetened beverages and fructose: what have we learned 10 years later.
Pediatr Obes, 8 (2013), pp. 242-248
K.M. Flegal, B.K. Kit, H. Orpana, B.I. Graubard.
Association of all-cause mortality with overweight and obesity using standard body mass index categories: a systematic review and meta-analysis.
K.A. Britton, J.M. Massaro, J.M. Murabito, B.E. Kreger, U. Hoffmann, C.S. Fox.
Body fat distribution, incident cardiovascular disease, cancer, and all-cause mortality.
A. Siebenhofer, K. Jeitler, K. Horvath, A. Berghold, U. Siering, T. Semlitsch.
Long-term effects of weight-reducing drugs in hypertensive patients.
Cochrane Database Syst Rev, 3 (2013), pp. CD007654
H.R. Wyatt.
Update on treatment strategies for obesity.
J Clin Endocrinol Metab, 98 (2013), pp. 1299-1306
L. Trigueros, S. Peña, A.V. Ugidos, E. Sayas-Barberá, J.A. Pérez-Álvarez, E. Sendra.
Food ingredients as anti-obesity agents: a review.
Crit Rev Food Sci Nutr, 53 (2013), pp. 929-942
K.J. Neff, C.W. Le Roux.
Bariatric surgery: the indications in metabolic disease.
Dig Surg, 30 (2013), pp. 183-189
J.M. Fort, R. Vilallonga, A. Lecube, O. Gonzalez, E. Caubet, J. Mesa, et al.
Bariatric surgery outcomes in a European Centre of Excellence (CoE).
Obes Surg, 23 (2013), pp. 1324-1332
J.I. Mechanick, A. Youdim, D.B. Jones, W.T. Garvey, D.L. Hurley, M.M. McMahon, et al.
Clinical practice guidelines for the perioperative nutritional, metabolic, and nonsurgical support of the bariatric surgery patient—2013 update: cosponsored by American Association of Clinical Endocrinologists, the Obesity Society, and American Society for Metabolic & Bariatric Surgery.
Endocr Pract, 19 (2013), pp. 337-372
V. Martínez-Vizcaíno, M. Sánchez-López, F. Salcedo-Aguilar, B. Notario-Pacheco, M. Solera-Martínez, P. Moya-Martínez, grupo MOVI-2, et al.
Protocolo de un ensayo aleatorizado de clusters para evaluar la efectividad del programa grupo MOVI-2. en la prevención del sobrepeso en escolares.
Rev Esp Cardiol, 65 (2012), pp. 427-433
M.N. McDonnell, S.L. Hillier, S.P. Hooker, A. Le, S.E. Judd, V.J. Howard.
Physical activity frequency and risk of incident stroke in a national US study of blacks and whites.
Stroke, 44 (2013), pp. 2519-2524
F.J. Dangardt, W.J. McKenna, T.F. Lüscher, J.E. Deanfield.
Exercise: friend or foe?.
Nat Rev Cardiol, 10 (2013), pp. 495-507
A. Pardo, J. McKenna, A. Mitjans, B. Camps, S. Aranda-García, J. Garcia-Gil, et al.
Physical activity level and lifestyle-related risk factors from Catalan physicians.
J Phys Act Health, (2013 Jun 24),
T.P. Baggett, M.L. Tobey, N.A. Rigotti.
Tobacco use among homeless people—Addressing the neglected addiction.
N Engl J Med, 369 (2013), pp. 201-204
U. Kwapisz, G. Baczyk.
Psycho-social context of health self-esteem in elderly ex-smokers.
Przegl Lek, 69 (2012), pp. 947-952
E. Valdivieso-López, G. Flores-Mateo, Molina-Gómez, C. Rey-Reñones, M.L. Barreira Uriarte, J. Duch, et al.
Efficacy of a mobile application for smoking cessation in young people: study protocol for a clustered, randomized trial.
BMC Public Health, 13 (2013), pp. 704
S.M. Vambheim, S.C. Wangberg, J.A. Johnsen, R. Wynn.
Language use in an internet support group for smoking cessation: development of sense of community.
Inform Health Soc Care, 38 (2013), pp. 67-78
K.V. Rankin.
E-cigarettes: What's known, what's unknown.
Tex Dent J, 130 (2013), pp. 446-452
E. Kralikova, A. Kmetova, L. Stepankova, K. Zvolska, R. Davis, R. West.
Fifty-two-week continuous abstinence rates of smokers being treated with varenicline versus nicotine replacement therapy.
Addiction, 108 (2013), pp. 1497-1502
R.M. Anthenelli.
Varenicline increases smoking cessation in subjects with depression: a randomized, placebo-controlled trial. Poster presented at the 166th Annual Meeting American Psychiatric Association; May 18-22.
Estados Unidos, (2013),
O. García-Rodríguez, R. Suárez-Vázquez, F.J. Santonja-Gómez, R. Secades-Villa, E. Sánchez-Hervás.
Psychosocial risk factors for adolescent smoking: A school-based study.
Int J Clin Health Psychol, 11 (2010), pp. 23-33
A. Cordero, V. Bertomeu-Martínez, P. Mazón, J. Cosín, E. Galve, I. Lekuona, et al.
Actitud y eficacia de los cardiólogos frente al tabaquismo de los pacientes tras un síndrome coronario agudo.
Rev Esp Cardiol, 65 (2012), pp. 719-725
J. Fernández de Bobadilla, D. Regina, E. Galve, grupo «Legislación del Tabaco y Síndrome Coronario Agudo en España».
Impacto de la legislación que prohíbe fumar en lugares públicos en la reducción de la incidencia de síndrome coronario agudo en España.
Rev Esp Cardiol, (2013),
HPS2-THRIVE Collaborative Group.
HPS2-THRIVE randomized placebo-controlled trial in 25 673 high-risk patients of ER niacin/laropiprant: trial design, pre-specified muscle and liver outcomes, and reasons for stopping study treatment.
Eur Heart J, 34 (2013), pp. 1279-1291
T.J. Anderson, J. Gregoire, R.A. Hegele, P. Couture, G.B. Mancini, R. McPherson, et al.
2012 update of the Canadian Cardiovascular Society guidelines for the diagnosis and treatment of dyslipidemia for the prevention of cardiovascular disease in the adult.
Can J Cardiol, 29 (2013), pp. 151-167
E.A. Stein, S. Mellis, G.D. Yancopoulos, N. Stahl, D. Logan, W.B. Smith, et al.
Effect of a monoclonal antibody to PCSK9 on LDL cholesterol.
N Engl J Med, 366 (2012), pp. 1108-1118
N.R. Desai, P. Kohli, R.P. Giugliano, M.L. O’Donoghue, R. Somaratne, J. Zhou, et al.
AMG145, a monoclonal antibody against proprotein convertase subtilisin kexin type 9, significantly reduces lipoprotein(a) in hypercholesterolemic patients receiving statin therapy: an analysis from the LDL-c assessment with proprotein convertase subtilisin kexin type 9 monoclonal antibody inhibition combined with statin therapy (LAPLACE)-Thrombolysis in Myocardial Infarction (TIMI) 57 trial.
Circulation, 128 (2013), pp. 962-969
S.G. Hitinder, S. Milan, J. Kooiman, D. Share.
A novel tool for reliable and accurate prediction of renal complications in patients undergoing percutaneous coronary intervention.
J Am Coll Cardiol, 61 (2013), pp. 2242-2248
Blue Cross and Blue Shield Michigan Cardiovascular Consortium (BMC2). CIN Calculator. Michigan: Universidad de Michigan; 2009 [accessed 10 Set 2013]. Available at:
KDIGO 2012 clinical practice guideline for the evaluation and management of chronic kidney disease.
Kidney Int Suppl, 3 (2013), pp. 1-163
G. Mancia, R. Fagard, K. Narkiewicz, J. Redón, A. Zanchetti, M. Böhm, et al.
2013 ESH/ESC Guidelines for the management of arterial hypertension: The Task Force for the management of arterial hypertension of the European Society of Hypertension (ESH) and of the European Society of Cardiology (ESC).
J Hypertens, 31 (2013), pp. 1281-1357
F.J. He, J. Li, G.A. Macgregor.
Effect of longer term modest salt reduction on blood pressure: Cochrane systematic review and meta-analysis of randomised trials.
BMJ, 346 (2013), pp. f1325
N.J. Aburto, A. Ziolkovska, L. Hooper, P. Elliott, F.P. Cappuccio, J.J. Meerpohl.
Effect of lower sodium intake on health: systematic review and meta-analyses.
BMJ, 346 (2013), pp. f1326
A. Fontenla, J.A. García-Donaire, F. Hernández, J. Segura, R. Salgado, C. Cerezo, et al.
Manejo de la hipertensión resistente en una unidad multidisciplinaria de denervación renal: protocolo y resultados.
Rev Esp Cardiol, 66 (2013), pp. 364-370
J.L. Llisterri, G.C. Rodríguez-Roca, C. Escobar, F.J. Alonso-Moreno, M.A. Prieto, V. Barrios, et al.
Treatment and blood pressure control in Spain during 2002-2010.
J Hypertens, 30 (2012), pp. 2425-2431
R.R. Wing, P. Bolin, F.L. Brancati, G.A. Bray, J.M. Clark, M. Coday, Look AHEAD Research Group, et al.
Cardiovascular effects of intensive lifestyle intervention in type 2 diabetes.
N Engl J Med, 369 (2013), pp. 145-154
H.C. Gerstein, J. Bosch, G.R. Dagenais, R. Díaz, H. Jung, A.P. Maggioni, ORIGIN Trial Investigators, et al.
Basal insulin and cardiovascular and other outcomes in dysglycemia.
N Engl J Med, 367 (2012), pp. 319-328
B.M. Scirica, D.L. Bhatt, E. Braunwald, P.G. Steg, J. Davidson, B. Hirshberg, et al.
SAVOR-TIMI 53 Steering Committee and Investigators. Saxagliptin and cardiovascular outcomes in patients wth type 2 diabetes mellitus.
N Engl J Med, 369 (2013), pp. 1317-1326
W.B. White, C.P. Cannon, S.R. Heller, S.E. Nissen, R.M. Bergenstal, G.L. Bakris, EXAMINE Investigators, et al.
Alogliptin after acute coronary syndrome in patients with type 2 diabetes.
N Engl J Med, 369 (2013), pp. 1327-1335
L. Rydén, P.J. Grant, S.D. Anker, C. Berna, F. Cosentino, N. Danchin, et al.
Comité de la ESC para las Guías de Práctica Clínica. Guía de práctica clínica de la ESC sobre diabetes, prediabetes y enfermedad cardiovascular, en colaboración con la European Society for the Study of Diabetes.
Rev Esp Cardiol, 67 (2014),
M. Cobo-Marcos, S. Cuenca, J.M. Gámez Martínez, B. Bornstein, V.T. Ripoll, P. García-Pavía.
Utilidad del análisis genético de la miocardiopatía hipertrófica en la práctica real.
Rev Esp Cardiol, 66 (2013), pp. 746-747
O. Companioni, E.F. Rodríguez, A.M. Fernández-Aceituno, J.C. Rodríguez Pérez.
Variantes genéticas, riesgo cardiovascular y estudios de asociación de genoma completo.
Rev Esp Cardiol, 64 (2011), pp. 509-514
P. Deloukas, S. Kanoni, C. Willenborg, M. Farrall, T.L. Assimes, J.R. Thompson, et al.
Large-scale association analysis identifies new risk loci for coronary artery disease.
Nat Genet, 45 (2013), pp. 25-33
T.A. Manolio.
Bringing genome-wide association findings into clinical use.
Nat Rev Genet, 14 (2013), pp. 549-558
E.M. Roth, J.M. McKenney, C. Hanotin, G. Asset, E.A. Stein.
Atorvastatin with or without an antibody to PCSK9 in primary hypercholesterolemia.
N Engl J Med, 367 (2012), pp. 1891-1900
B.F. Voight, G.M. Peloso, M. Orho-Melander, R. Frikke-Schmidt, M. Barbalic, M.K. Jensen, et al.
Plasma HDL cholesterol and risk of myocardial infarction: a mendelian randomisation study.
C. Lluis-Ganella, I. Subirana, G. Lucas, M. Tomas, D. Munoz, M. Senti, et al.
Assessment of the value of a genetic risk score in improving the estimation of coronary risk.
Atherosclerosis, 222 (2012), pp. 456-463
E. Tikkanen, A.S. Havulinna, A. Palotie, V. Salomaa, S. Ripatti.
Genetic risk prediction and a 2-stage risk screening strategy for coronary heart disease.
Arterioscler Thromb Vasc Biol, 33 (2013), pp. 2261-2266
J.J. Verschuren, S. Trompet, J.A. Wessels, H.J. Guchelaar, M.P. De Maat, M.L. Simoons, et al.
A systematic review on pharmacogenetics in cardiovascular disease: is it ready for clinical application?.
Eur Heart J, 33 (2012), pp. 165-175
D.R. Holmes Jr., G.J. Dehmer, S. Kaul, D. Leifer, P.T. O’Gara, C.M. Stein.
ACCF/AHA Clopidogrel clinical alert: approaches to the FDA “boxed warning”: a report of the American College of Cardiology Foundation Task Force on Clinical Expert Consensus Documents and the American Heart Association.
Circulation, 122 (2010), pp. 537-557
M. Zabalza, I. Subirana, J. Sala, C. Lluis-Ganella, G. Lucas, M. Tomas, et al.
Meta-analyses of the association between cytochrome CYP2C19 loss- and gain-of-function polymorphisms and cardiovascular outcomes in patients with coronary artery disease treated with clopidogrel.
Heart, 98 (2012), pp. 100-108
M.F. Piepoli, U. Corra, W. Benzer, B. Bjarnason-Wehrens, P. Dendale, D. Gaita, et al.
Secondary prevention through cardiac rehabilitation: from knowledge to implementation. A position paper from the Cardiac Rehabilitation Section of the European Association of Cardiovascular Prevention and Rehabilitation.
Eur J Cardiovasc Prev Rehabil, 17 (2010), pp. 1-17
S. Smith, E. Benjamin, R. Bonow, L. Braun, M. Creager, B. Franklin, et al.
AHA/ACCF secondary prevention and risk reduction therapy for patients with coronary and other atherosclerotic vascular disease: 2011 update. A guideline from the American Heart Association and American College of Cardiology Foundation.
J Am Coll Cardiol, 58 (2011), pp. 2432-2446
F. Worner, A. Cequier, A. Bardají, A. Bodí, R. Bover, M. Martínez-Sellés, et al.
Comentarios a la guía de práctica clínica de la ESC para el manejo del infarto agudo de miocardio en pacientes con elevación del segmento ST.
Rev Esp Cardiol, 66 (2013), pp. 5-11
B.S. Heran, J.M. Chen, S. Ebrahim, T. Moxham, N. Oldridge, K. Rees, et al.
Exercise-based cardiac rehabilitation for coronary heart disease.
Cochrane Database Syst Rev, 1 (2011), pp. CD001800
B. Rauch, T. Riemer, B. Schwaab, S. Schneider, F. Diller, H. Gohlke, OMEGA study group, et al.
Short-term comprehensive cardiac rehabilitation after AMI is associated with reduced 1-year mortality: results from the OMEGA study.
Eur J Prev Cardiol, (2013),
A.M. Clark, K.M. King-Shier, A. Duncan, M. Spaling, J.A. Stone, S. Jaglal, et al.
Factors influencing referral to cardiac rehabilitation and secondary prevention programs: a systematic review.
Eur J Prev Cardiol, 20 (2013), pp. 692-700
S.L. Grace, Y.W. Leung, R. Reid, P. Oh, G. Wu, D.A. Alter, CRCARE Investigators.
The role of systematic inpatient cardiac rehabilitation referral in increasing equitable access and utilization.
J Cardiopulm Rehabil Prev, 32 (2012), pp. 41-47
R.A. Clark, A. Conway, V. Poulsen, W. Keech, R. Tirimacco, P. Tideman.
Alternative models of cardiac rehabilitation: a systematic review.
Eur J Prev Cardiol, (2013),
E. Piotrowicz, R. Piotrowicz.
Cardiac telerehabilitation: current situation and future challenges.
Eur J Prev Cardiol, 20 (2013), pp. 12-16
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Revista Española de Cardiología (English Edition)

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