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Vol. 74. Issue 2.
Pages 191-194 (February 2021)
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Vol. 74. Issue 2.
Pages 191-194 (February 2021)
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Apical ventricular hypertrophy in the transplanted heart: a 20-year single-center experience
Hipertrofia ventricular apical en el corazón trasplantado: experiencia de un centro en 20 años
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Lourdes Vicenta, Juan Fernández-Yáñezb, Roberto Mateosb, Iago Sousa-Casasnovasb, Francisco Fernández-Avilésb,c,, Manuel Martínez-Sellésb,c,d,,
Corresponding author
mmselles@secardiologia.es

Corresponding author:
a Servicio de Cardiología, Hospital Universitario 12 de Octubre, Madrid, Spain
b Servicio de Cardiología, Hospital General Universitario Gregorio Marañón, CIBERCV, Madrid, Spain
c Facultad de Medicina, Universidad Complutense de Madrid, Madrid, Spain
d Facultad de Medicina, Universidad Europea de Madrid, Madrid, Spain
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Table 1. Patients with apical ventricular hypertrophy following heart transplant
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To the Editor,

Left ventricular hypertrophy (LVH) is a common finding after heart transplant (HTx)1 and is associated with a less favorable prognosis. Several variables have been related to a higher risk of severe LVH following transplant, such as patient age, obesity, prior diabetes or hypertension,1 immunosuppressive therapy, and the possible presence of a primary graft disease that manifests after transplant.

Apical hypertrophic cardiomyopathy is a relatively uncommon variant, associated with increased wall thickness of the left ventricular apical segments and a reduction in the ventricular cavity.3 The symptoms are nonspecific and diagnosis is often delayed.3,4 The objective of our study was to describe the characteristics and clinical course of a cohort of patients with apical LVH following HTx.

A search was carried out in patients who had undergone HTx since 1988, in active follow-up. Apical LVH was defined by myocardial thickness> 15 mm in the apex of the left ventricle, or> 13 mm with a ratio of basal to apical segments> 1.5.5 Eight cases of apical LVH were identified in the total of 233 transplant recipients alive and under follow-up (prevalence 3.4%). Mean age at diagnosis was 56.4± 8.8 years, and there was a higher percentage of women in this group than among patients without LVH (62.5% vs 26.2%, respectively).

The most common reason for transplant in patients with apical LVH was dilated cardiomyopathy: 5 patients (62.5%) (table 1). None of the donor hearts showed significant LVH (on echocardiography performed in the donor's center of origin), and ventricular function was within the normal limits. Following transplant, all patients received an immunosuppressive regimen that included a calcineurin inhibitor, but in 1 case this was replaced by everolimus before the LVH diagnosis due to graft vascular disease in a patient with renal failure. In 2 other patients a change to everolimus was made after the LVH diagnosis, but no significant regression of the condition has been observed to date (1 and 2 years, respectively, of follow-up). In all cases, electrocardiograms showed a characteristic LVH pattern, with increased voltages and giant negative T waves in the precordial leads (figure 1). Cardiac magnetic resonance confirmed the diagnosis in the 4 patients who underwent this examination. Apical aneurysms were not observed in any of the patients. Two patients had “mixed” septal and apical hypertrophy, with no differences in the form of presentation or clinical course of the condition. In the follow-up endomyocardial biopsy specimens after HTx, there were no features indicating endomyocardial fibrosis, eosinophilia, or significant fibrosis.

Table 1.

Patients with apical ventricular hypertrophy following heart transplant

BNP, brain natriuretic propeptide; CAV, cardiac allograft vasculopathy, nomenclature of the International Society for Heart and Lung Transplantation: CAV 0 (not significant), CAV 1 (mild), CAV 2 (moderate), and CAV 3 (severe); CVRF, cardiovascular risk factors; GVD, graft vascular disease; HTx, heart transplant; LVH, left ventricular hypertrophy; MR, magnetic resonance; NT-proBNP, amino-terminal fraction of brain natriuretic propeptide; NYHA, New York Heart Association.

*

The tacrolimus doses used were <15mg/mL in all cases.

Figure 1.

Electrocardiograms showing characteristic features of apical ventricular hypertrophy in 2 patients following heart transplant. A: complete right bundle branch block with increased voltages and criteria indicating left ventricular hypertrophy. B: increased voltages with criteria of left ventricular hypertrophy and deep T-wave inversion in the precordial leads.

(0.9MB).

None of the patients with apical LVH following transplant had to be hospitalized for heart failure, malignant ventricular arrhythmias, or sudden cardiac death. The predominant symptom was exertional dyspnea, (7 patients, 87.5%). One previously reported case of LVH following HTx also had a benign clinical course.6 Among the total, only 1 patient had repeated episodes of syncope; head trauma occurring in 1 of the episodes led to intracranial bleeding and death.

Although LVH was severe in all cases, most patients in our series showed no significant clinical consequences. The most common symptom was functional class deterioration. This outcome is comparable to that of other cohorts with apical hypertrophic cardiomyopathy, who have shown low mortality and few adverse cardiovascular events.4,5 Although a considerable percentage of our apical LVH patients had a history of hypertension, it is unlikely that hypertension was the cause of the condition given the location of LVH and the cardiac magnetic resonance findings. The specific cause of LVH was not identified after excluding rejection and microbiological causes such as cytomegalovirus infection. Of particular note, an uncommon adverse effect of calcineurin inhibitors is LVH,2 as described in patients receiving these drugs for immunosuppressive therapy in autoimmune diseases, hematologic malignancies, and solid organ transplantation. The origin of apical LVH in our patients would likely be multifactorial, including the action of cytokines, hemodynamic overload, and possible sarcomeric cardiomyopathy in the donor that could develop later. The most important limitations of the present study are the small number of cases of apical LVH and the disparity in the length of follow-up (between 1 and 14 years).

This is the first study to date describing a consecutive series of patients with apical LVH following HTx, which is likely an underdiagnosed condition. The patients’ clinical course was benign in most cases.

References
[1]
R. Goodroe, D.D. Bonnema, S. Lunsford, et al.
Severe left ventricular hypertrophy 1 year after transplant predicts mortality in cardiac transplant recipients.
J Heart Lung Transplant., 26 (2007), pp. 145-151
[2]
Y. Nakata, M. Yoshibayashi, T. Yonemura, et al.
Tacrolimus and myocardial hypertrophy.
Transplantation., 69 (2000), pp. 1960-1962
[3]
R.K. Hughes, K.D. Knott, J. Malcolmson, et al.
Apical hypertrophic cardiomyopathy: the variant less known.
J Am Heart Assoc., (2020),
[4]
E.K. Kim, S.-C. Lee, J.W. Hwang, et al.
Differences in apical and non-apical types of hypertrophic cardiomyopathy: a prospective analysis of clinical, echocardiographic, and cardiac magnetic resonance findings and outcome from 350 patients.
Eur Heart J Cardiovasc Imaging., 17 (2015), pp. 678-686
[5]
M.J. Eriksson, B. Sonnenberg, A. Woo, et al.
Long-term outcome in patients with apical hypertrophic cardiomyopathy.
J Am Coll Cardiol., 39 (2002), pp. 638-645
[6]
U. Ibe, K. Balakumaran, S. Arora.
Left ventricular apical hypertrophy in a transplanted heart: a case report.
BMC Cardiovasc Disord., 19 (2019), pp. 81

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