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Vol. 69. Issue 4.
Pages 456-457 (April 2016)
Vol. 69. Issue 4.
Pages 456-457 (April 2016)
Letter to the Editor
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Coronary Obstruction During Transcatheter Aortic Valve Replacement: Related to Calcification or Thrombus?
Obstrucción coronaria durante el implante percutáneo de válvula aórtica: ¿relacionada con calcificación o con trombo?
Cengiz Ozturk
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Corresponding author:
, Ali Osman Yildirim, Mustafa Demir, Sevket Balta
Department of Cardiology, Gulhane Military Medical Academy, School of Medicine, Etlik-Ankara, Turkey
Related content
Rev Esp Cardiol. 2015;68:89310.1016/j.rec.2014.11.020
Ricardo Mori Junco, Francisco Domínguez Melcon, Mar Moreno Yangüela
Ricardo Mori Junco, Francisco Domínguez Melcón, Mar Moreno Yangüela
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To the Editor,

We read with great interest the recently published article by Mori Junco et al.1 This is a very interesting case successfully treated with thrombus aspiration and balloon dilatation. However, some issues require further discussion.

Although coronary thromboembolism during transcatheter aortic valve replacement (TAVI) is a rarely encountered complication, it may lead to life-threatening problems primarily due to acute myocardial infarction. The optimal treatment is percutaneous coronary intervention with angioplasty and stenting if necessary. Percutaneous coronary intervention may be a lifesaving strategy, especially in thromboembolism at the proximal coronary arterial tree. In the present case, a 74-year-old man had an acute myocardial infarction due to distal left main coronary thromboembolism during TAVI. TAVI is an alternative and effective treatment in patients with severe symptomatic aortic stenosis and high surgical risk.2,3 Even though TAVI is a less invasive treatment than surgical aortic valve replacement, some serious complications may develop. Some of these are aortic rupture,4,5 early aortic valve thrombosis, and peripheral and neurological embolization of aortic valve calcium following TAVI. In the present case, the 74-year-old man had a predisposition to thrombus formation related to hypertension, type 2 diabetes mellitus, diabetic nephropathy, and chronic alcoholic liver disease. Moreover, the authors state that 2 drug eluting stents had previously been implanted in the left anterior descending artery. Regarding drug eluting stent implantation, we wonder whether or not the patient took dual antiplatelet therapy and unfractionated heparin before the TAVI procedure. We strongly believe that thrombus to the distal left main artery may be closely related to antiplatelet and anticoagulant treatment in the present case.

On the other hand, calcifications extending to the ascending aorta or left ventricular outflow tract may lead to some complications such as systemic embolism, aortic annulus rupture, or coronary embolism. In addition, a prosthetic valve during the implantation procedure may also damage and obstruct the ostium of the left main artery.6–9 Lastly, laser aortic annulus and aortic root may be damaged iatrogenically at various levels during balloon inflation and valve implantation. Therefore, the landing zone of the valve and the direction of the annular calcification are very important to predict these complications.

Besides thrombus formation, residual calcification related to the natural valve is also a potential etiologic factor for embolism. Because of the potential catastrophic complications of TAVI, patients should be closely followed-up by echocardiography during and after the procedure. On echocardiography, detection of thrombus formation on the implanted aortic valve is essential after TAVI and interventional cardiologist should promptly start antiplatelet and antithrombotic treatment after TAVI in those patients.

In conclusion, it is very important to be aware of this catastrophic event and all interventional cardiologists should take all preventive actions such as placing a guiding catheter in the left coronary ostium.

R. Mori Junco, F. Domínguez Melcon, M. Moreno Yangüela.
Coronary Thromboembolism During Transcatheter Aortic Valve Replacement.
Rev Esp Cardiol., 68 (2015), pp. 893
J. Chandrasekhar, B. Hibbert, M. Ruel, B.K. Lam, M. Labinaz, C. Glover.
Transfemoral vs Non-transfemoral Access for Transcatheter Aortic Valve Implantation: A Systematic Review and Meta-analysis.
S. Demirkol, C. Ozturk, S. Balta, M. Unlu.
Right ventricular function in patients undergoing surgical or transcatheter aortic valve replacement.
Eur J Cardiothorac Surg., (2015),
pii: ezv307. [Epub ahead of print] No abstract available
C. Ozturk, S. Demirkol, M. Demir, A.O. Yildirim, S. Balta, T. Celik, et al.
Mobile mass lesion in the aorta after transcatheter aortic valve implantation: Thrombus or residue calcification.
Int J Cardiol., 198 (2015), pp. 45-46
A. Iyisoy, C. Ozturk, S. Demirkol, T. Celik, M. Aparci, M. Demir, et al.
Aortic and right ventricular rupture in a patient after transcatheter aortic valve implantation; The direction of the calcification predicts aortic annulus rupture.
Int J Cardiol., 193 (2015), pp. 49-52
J.G. Córdoba-Soriano, R. Puri, I. Amat-Santos, H.B. Ribeiro, O. Abdul-Jawad Altisent, M. del Trigo, et al.
Valve Thrombosis Following Transcatheter Aortic Valve Implantation: A Systematic Review.
Rev Esp Cardiol., 68 (2015), pp. 198-204
A. Ielasi, A. Latib, M. Montorfano, A. Colombo.
Sandwich Stenting to Treat an Ostial Left Main Narrowing Following Transcatheter Aortic Valve Implantation.
Rev Esp Cardiol., 64 (2011), pp. 1220-1222
S. Dağdelen, H. Gök, C. Alhan.
Acute left main coronary artery occlusion following TAVI and emergency solution.
Anatol J Cardiol., 11 (2011), pp. 747-748
O. Ergene, V. Emren, H. Duygu, N.K. Eren.
A case of occurring hemodynamic deterioration and ST-segment elevation during transcatheter aortic valve implantation.
Turk Kardiyol Dern Ars., 42 (2014), pp. 556-559
Copyright © 2016. Sociedad Española de Cardiología
Revista Española de Cardiología (English Edition)

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