Publish in this journal
Journal Information
Vol. 65. Issue 1.
Pages 97 (January 2012)
DOI: 10.1016/j.rec.2010.03.005
Full text access
Characterization of a Mediastinal Thymic Seminoma Using Cardiac Magnetic Resonance
Seminoma tímico mediastínico caracterizado mediante resonancia magnética cardiaca
Visits
...
Leticia Fernández-Frieraa,b,c, Valentín Fustera,c, Javier Sanza,
Corresponding author
javier.sanz@mssm.edu

Corresponding author: Javier.Sanz@mssm.edu
a The Zena and Michael A. Wiener Cardiovascular Institute, and Marie-Josée and Henry R. Kravis Center for Cardiovascular Health, Mount Sinai School of Medicine, New York, United States
b Departamento de Cardiología, Hospital Universitario Marqués de Valdecilla-Instituto de Formación e Investigación Marqués de Valdecilla (IFIMAV), Santander, Spain
c Fundación Centro Nacional de Investigaciones Cardiovasculares Carlos III (CNIC), Madrid, Spain
This item has received
...
Visits
(Daily data update)
Article information
Full Text
Download PDF
Statistics
Figures (3)
Show moreShow less
Full Text

A 34-year-old man was referred for evaluation of a mediastinal mass, detected on routine chest radiography (Figure 1A and 1B). His past medical history, physical examination, and laboratory tests were unremarkable. Cardiac magnetic resonance confirmed a well circumscribed mass in the anterior mediastinum, measuring 6×5×5cm. It started at the level of the pulmonary artery bifurcation and extended laterally to the right atrium, without evidence of infiltration of surrounding tissues. In comparison with the myocardium, the mass was isointense on T1-weighted imaging (Figure 2A) and hyperintense on T2 sequences (Figure 2B), findings compatible with high fluid content. On the other hand, first-pass images showed hyperperfusion within the mass (Figure 2C) and diffuse delayed enhancement (Figure 2D), suggesting a highly vascular component with increased interstitial space. The patient underwent surgical mass resection. Histological specimens showed a central component of large polygonal cells with clear cytoplasm and central nuclei with prominent nucleoli (Figure 3A and 3B). This morphologic finding together with immunohistochemical staining that was positive for placental alkaline phosphatase and negative for alpha-fetoprotein and human chorionic gonadotropin were consistent with thymic seminoma. Germ-cell tumors are the most common cancer in men between the ages of 15 and 35 years. The anterior mediastinum is the most common primary extragonadal site for seminoma. Because of its favorable prognosis, these variants should not be confused with other mediastinal tumors. A cardiac magnetic resonance provides a comprehensive characterization of this tumor, and should be considered when a mediastinal mass is discovered in a young male.

Figure 1.

Figure 2.

Figure 3.

Funding

This study was funded in part by the Sociedad Española de Cardiología and the Instituto de Formación e Investigación “Marqués de Valdecilla” (IFIMAV) in Santander, Spain.

Corresponding author: Javier.Sanz@mssm.edu

Idiomas
Revista Española de Cardiología (English Edition)

Subscribe to our newsletter

Article options
Tools
es en

¿Es usted profesional sanitario apto para prescribir o dispensar medicamentos?

Are you a health professional able to prescribe or dispense drugs?

es en
Política de cookies Cookies policy
Utilizamos cookies propias y de terceros para mejorar nuestros servicios y mostrarle publicidad relacionada con sus preferencias mediante el análisis de sus hábitos de navegación. Si continua navegando, consideramos que acepta su uso. Puede cambiar la configuración u obtener más información aquí. To improve our services and products, we use "cookies" (own or third parties authorized) to show advertising related to client preferences through the analyses of navigation customer behavior. Continuing navigation will be considered as acceptance of this use. You can change the settings or obtain more information by clicking here.